PMID: 9181634May 1, 1997Paper

Pharmacological interactions between serotonin and dopamine on behavior in the squirrel monkey

Psychopharmacology
Leonard L HowellL D Byrd

Abstract

The behavioral effects of GBR 12909, a selective dopamine uptake inhibitor, were determined in squirrel monkeys trained to respond under a fixed-interval (FI) schedule of stimulus termination and a second-order schedule of IV drug self-administration. Intermediate doses of GBR 12909 increased FI response rate markedly, and the highest dose decreased response rate below control values. The 5HT uptake inhibitors, alaproclate and fluoxetine, and the 5HT agonist, quipazine, attenuated the behavioral-stimulant effects of GBR 12909, whereas the 5HT2A/2C antagonist, ritanserin, enhanced the behavioral-stimulant effects of the lowest dose. GBR 12909 reliably maintained self-administration, and ritanserin increased response rate maintained by the highest dose. The dopamine agonist, quinpirole, increased FI response rate in only one of three subjects, and ritanserin enhanced the behavioral-stimulant effects of quinpirole in that subject. The dopamine agonist, apomorphine, only decreased FI response rate, and ritanserin did not alter its behavioral effects. The pharmacological profile of GBR 12909 administered alone and in combination with selective 5HT drugs in the present study was similar to that obtained previously with cocaine, furth...Continue Reading

Citations

Jan 15, 1999·American Journal of Primatology·S M Witte, J Rogers
Dec 22, 2000·Pharmacology, Biochemistry, and Behavior·P W Czoty, L L Howell
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Sara Jane WardDavid C S Roberts
Oct 29, 2008·Psychological Bulletin·Melissa A Cyders, Gregory T Smith
May 10, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Janusz BoryczSergi Ferré
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wai Chong WongMichela Marinelli
Jul 1, 2008·Behavioural Brain Research·Samuel Thuu Kimani, Albert Wafula Nyongesa
Nov 11, 2008·Annals of the New York Academy of Sciences·Leonard L Howell, Kevin S Murnane
Nov 16, 2006·Annals of the New York Academy of Sciences·Richard B Rothman, Michael H Baumann
Sep 11, 2007·Biochemical Pharmacology·Leonard L Howell, Heather L Kimmel
Feb 28, 2002·The Journal of Pharmacology and Experimental Therapeutics·Paul W CzotyLeonard L Howell
Jul 9, 2004·The Journal of Pharmacology and Experimental Therapeutics·Paul W CzotyJack Bergman
Jun 14, 2019·Frontiers in Psychiatry·Meredith HalcombMelissa A Cyders
Jul 30, 1999·Journal of Medicinal Chemistry·F I CarrollM J Kuhar

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