Pharmacological intervention of tiferron and propolis to alleviate beryllium-induced hepatorenal toxicity

Fundamental & Clinical Pharmacology
Satendra Kumar NiralaRamesh Mathur

Abstract

Intervention of chelating agent tiferron (sodium-4,5-dihydroxy-1,3-benzene disulfonate; 300 mg/kg, intraperitoneal) with propolis (honey beehive product; 200 mg/kg, p.o.) was evaluated to encounter the characteristic biochemical and ultra-morphological alterations following subchronic exposure to beryllium. Female albino rats were challenged with beryllium nitrate (1 mg/kg, i.p.) daily for 28 days followed by treatment of the above-mentioned therapeutic agents either individually or in combination for five consecutive days. Exposure to beryllium increased its concentration in the serum, liver and kidney, and caused significant alterations in cytochrome P450 activity, microsomal lipid peroxidation and proteins. Activities of alkaline phosphatase, lactate dehydrogenase, gamma-glutamyl transpeptidase, bilirubin, creatinine and urea in the serum and activity of acid phosphatase, alkaline phosphatase, adenosine triphosphatase, glucose-6-phophatase and succinic dehydrogenase in the liver and kidney were significantly altered after beryllium administration. Beryllium exposure also induced severe hepatorenal alterations at histopathological and ultra-morphological level. Tiferron along with propolis dramatically reversed the alteration...Continue Reading

References

Jan 1, 1976·Annual Review of Biochemistry·A Meister, S S Tate
Jan 1, 1978·Methods in Enzymology·J B Schenkman, D L Cinti
Jan 1, 1966·The Biochemical Journal·M Thomas, W N Aldridge
Nov 1, 1967·The Biochemical Journal·M A Verity, A Reith
Dec 1, 1966·The Journal of Pharmacy and Pharmacology·P K Seth, K K Tangri
Feb 1, 1968·Journal of Neurochemistry·S K Sharma, C R Krishna Murti
Sep 1, 1968·American Industrial Hygiene Association Journal·D L Bokowski
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·C E Pickering, R G Pickering
Jul 1, 1995·Journal of Applied Toxicology : JAT·D J SánchezJ Corbella
Mar 1, 1995·Reproductive Toxicology·J L Domingo
Jan 1, 1994·Journal of Ethnopharmacology·C PascualR G Torricella
Jan 1, 1995·Archives of Toxicology·M A BosqueJ Corbella
Jul 3, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G A Burdock
Jun 11, 1999·Journal of Ethnopharmacology·A KujumgievS Popov
Aug 16, 2000·Journal of Applied Toxicology : JAT·P SharmaS Shukla
May 24, 2001·Applied Occupational and Environmental Hygiene·M E Kolanz
Jun 2, 2001·Stroke; a Journal of Cerebral Circulation·R M BryanS P Marrelli
Oct 1, 1952·The Biochemical Journal·E C SLATER, W D BORNER
Oct 7, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·A AteşşahinI Princci
Apr 20, 2004·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Hakim BoukhalfaAlvin L Crumbliss
Jul 21, 2004·Journal of Ethnopharmacology·L M C SimõesY M Lucisano-Valim
Aug 7, 2004·The Hematology Journal : the Official Journal of the European Haematology Association·Massimo Franchini, Dino Veneri
Aug 2, 2005·Mutation Research·Ainsley WestonEugene Demchuk
Apr 6, 2007·Molecular and Cellular Biochemistry·Monika BhadauriaSangeeta Shukla

❮ Previous
Next ❯

Citations

Jul 26, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Wei ZhuFuliang Hu
Sep 27, 2013·BioMed Research International·Somia A NassarSoad M Nasr
Jul 20, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hasan TürkezFatime Geyikoglu
May 9, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Al-Sayeda A NewairyMokhtar I Yousef
Oct 4, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hasan TürkezFatime Geyikoglu
Jan 19, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Monika Bhadauria
Dec 7, 2016·Journal of Zhejiang University. Science. B·Zi-Li MaYuan-Shu Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.