Pharmacological interventions for epilepsy in people with intellectual disabilities

The Cochrane Database of Systematic Reviews
Cerian F JacksonMichael Kerr

Abstract

The prevalence of epilepsy among people with intellectual disabilities is much higher than in the general population. Seizures in this population are often complex and refractory to treatment and antiepileptic medication may have a profound effect upon behaviour (Kerr 1997).This is an updated version of a Cochrane Review first published in Issue 3, 2007. To assess the data available from randomised controlled trials (RCTs) of the efficacy of antiepileptic drug (AED) interventions in people with epilepsy and intellectual disabilities. For the latest update of this review, we searched the Cochrane Epilepsy Group Specialised Register (2 September 2014), the Cochrane Central Register of Controlled Trials (CENTRAL) via the Cochrane Register of Studies Online (CRSO) (2 September 2014), MEDLINE (Ovid, 1946 to 3 September 2014) and PsycINFO (EBSCOhost, 1887 to 3 September 2014). Randomised and quasi-randomised controlled trials (RCTs) of pharmacological interventions for people with epilepsy and a learning disability. Two review authors independently assessed trial quality and extracted data. We contacted study authors for additional information. We assessed epilepsy/seizure, behavioural and cognitive outcomes, as well as quality of li...Continue Reading

References

Aug 1, 1992·Journal of Intellectual Disability Research : JIDR·N Bouras, C Drummond
Jun 1, 1991·Journal of Medical Genetics·D W WebbJ P Osborne
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Jan 1, 1991·Journal of Child Neurology·O DulacS Mondragon
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Oct 1, 1994·Developmental Medicine and Child Neurology·E Schlumberger, O Dulac
Jan 7, 1993·The New England Journal of Medicine·UNKNOWN Felbamate Study Group in Lennox-Gastaut Syndrome
Jan 1, 1996·Epilepsia·D O LeeM A Mikati
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Dec 1, 1996·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·S J Wallace
May 1, 1997·Comprehensive Psychiatry·S Deb
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Jul 25, 2000·The Cochrane Database of Systematic Reviews·S RamaratnamG A Baker
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Nov 1, 2001·The Cochrane Database of Systematic Reviews·S RamaratnamG A Baker
Aug 7, 2003·American Journal of Mental Retardation : AJMR·Christopher Ll MorganMichael P Kerr
Aug 23, 2006·Neurology·F DonatiUNKNOWN Oxcarbazepine Cognitive Study Group
Jul 20, 2007·The Cochrane Database of Systematic Reviews·J BeavisA G Marson
Apr 22, 2008·The Cochrane Database of Systematic Reviews·B Michael, A G Marson
Feb 17, 2010·BMJ : British Medical Journal·Jamie J KirkhamPaula R Williamson
Mar 24, 2011·Journal of Child Neurology·Eveline E O HagebeukBwee-Tien Poll-The
Oct 1, 2011·Neurology·Y T NgUNKNOWN OV-1012 Study Investigators

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