Pharmacological interventions for treating sialorrhea associated with neurological disorders: A mixed treatment network meta-analysis of randomized controlled trials

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Kannan Sridharan, Gowri Sivaramakrishnan

Abstract

Sialorrhea is a common distress associated with certain neurological disorders. The aim of this study is to compare the pharmacological agents used for treating sialorrhea by network meta-analysis. Electronic databases were searched for randomized clinical trials comparing active drugs with either placebo or other active drugs. Total drooling scores was the primary outcome measure. Inverse variance heterogeneity model was used for both direct and mixed treatment comparison analysis. Twenty one studies were included in the systematic review and 15 in the meta-analysis. Compared to placebo, benztropine, botulinum toxins A and B are associated with a significant reduction in the frequency and severity of drooling both in the overall neurological disorders as well as for children with cerebral palsy. Only botulinum toxin A and B were associated with significant therapeutic effects in Parkinson's disease. Benztropine and botulinum toxins A and B were observed to be effective in reducing sialorrhea associated with neurological disorders.

Citations

May 31, 2018·Toxins·Javier Martínez-PolesAraceli Alonso-Canovas
Feb 2, 2021·Expert Review of Neurotherapeutics·Katarina RukavinaK Ray Chaudhuri
Aug 27, 2021·Frontiers in Pediatrics·John AllenEleanor J Molloy
Aug 28, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Ya-Chien YuYi-Chun Kuan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Botulism (ASM)

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Botulism

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

Related Papers

Developmental Medicine and Child Neurology
Dinah Reddihough, H Kerr Graham
Movement Disorders : Official Journal of the Movement Disorder Society
W H Jost
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Rishi VashishtaM Boyd Gillespie
© 2022 Meta ULC. All rights reserved