PMID: 6126561Aug 1, 1982

Pharmacological isolation of a single beta-adrenoceptor subtype makes Schild plots which have slopes of 1 possible for selective beta-adrenoceptor antagonists in carbachol-contracted guinea-pig trachea

The Journal of Pharmacy and Pharmacology
S E Taylor

Abstract

The effects of selective beta-adrenoceptor agonists and antagonists on isometric relaxation of carbachol-contracted, guinea-pig isolated trachea were studied. An attempt was made to pharmacologically isolate the beta 1- and beta 2-adrenoceptors by use of appropriate selective agonists and antagonists. The slopes of the Schild plots for butoxamine vs noradrenaline and terbutaline as well as for practolol vs terbutaline did not differ significantly from 1, the predicted value for a competitive antagonist acting at a single receptor type. These data differ from a previous report suggesting that slopes of less than 1 are characteristic for selective beta-adrenoceptor antagonists in carbachol-contracted guinea-pig trachea. They support the hypothesis that the slopes in this preparation are due to interaction of the agonist with both beta 1- and beta 2-adrenoceptors rather than the state of contraction of the trachea.

References

Jul 1, 1977·British Journal of Pharmacology·J L ImbsC G Wermuth
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD

Related Concepts

Adrenergic beta-Antagonists
Butoxamine Hydrochloride
Carboptic
Cavia porcellus
Inotropism
Smooth Muscle
Norepinephrine, (+, -)-Isomer
Dalzic
Norepinephrine Receptors
Beta-adrenergic receptor

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.