PMID: 18193713Jan 16, 2008Paper

Pharmacological management of hypertension

Clinical Medicine : Journal of the Royal College of Physicians of London
Bernard HigginsGuideline Development Group

Abstract

Hypertension is a major risk factor for cardiovascular disease, and is both common and amenable to treatment. Several major new studies have appeared recently and in response the National Institute for Health and Clinical Excellence and the British Hypertension Society have collaborated to update their respective guidelines on primary hypertension, and to agree joint recommendations. The update focuses only on pharmacological aspects of treatment. Wherever possible, the recommendations are based on the clinical outcomes of mortality, stroke, myocardial infarction, heart failure, and new onset diabetes mellitus, rather than on blood pressure lowering. A brief treatment algorithm is included. In summary, either calcium channel inhibitors or thiazide-type diuretics should be the preferred initial agent for use in primary hypertension in most patients, although angiotensin converting enzyme (ACE) inhibitors (including angiotensin-II receptor inhibitors if ACE-intolerant) are preferred in patients younger than 55.

Citations

Jun 20, 2008·Lancet·Bryan WilliamsPeter Sever
Jul 22, 2009·Journal of Strength and Conditioning Research·Jay R HoffmanAlan D Rogol
Oct 9, 2007·Disability and Rehabilitation·Lynne Turner-Stokes
Feb 2, 2010·Journal of the American College of Cardiology·Bryan Williams
May 3, 2008·Journal of the American College of Cardiology·Bryan Williams
Nov 7, 2016·Journal of Biotechnology·Celma Estefanía Ochoa-MéndezRuth Elena Soria-Guerra
Mar 3, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Gregory OndiekiXin He
Jun 16, 2009·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·Bryan Williams

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