PMID: 8938603Oct 1, 1996Paper

Pharmacological management of spinal cord injury: current status of drugs designed to augment functional recovery of the injured human spinal cord

Journal of Spinal Disorders
K A GreeneV K Sonntag

Abstract

Spinal cord injury often results in devastating physical, psychological, and economic disabilities. Research efforts are directed toward providing prognostic outcome data and animal models that parallel the human disorder, thereby elucidating the mechanisms responsible for its dismal clinical prognosis. Investigators continue to search for pharmacological agents that halt the cascade of events that lead to loss of function after cord injury. The scientific and federal regulatory processes by which new drugs are discovered and implemented clinically permit clinicians to evaluate the potential benefits of any new agent, and provide an estimate of the duration required for promising new agents to be made clinically available. Understanding these processes makes the task of classifying the availability status of new drugs much simpler, allowing rational dissemination of realistic information to patients and their families frequently made desperate for viable alternatives to the prospect of permanent paralysis. In this review, we describe the scientific and regulatory processes necessary for the clinical introduction of new drugs using spinal cord injury as an example. A classification scheme based on current Food and Drug Administr...Continue Reading

Citations

Oct 14, 1998·Progress in Neurobiology·Y Taoka, K Okajima
Nov 1, 2003·The Spine Journal : Official Journal of the North American Spine Society·Gregory D Carlson, Carey Gorden
Jan 26, 2000·Critical Care Nursing Quarterly·E C Seidl
Jul 12, 2008·Expert Opinion on Investigational Drugs·Paul A Lapchak
Dec 7, 2007·British Journal of Pharmacology·T GenoveseS Cuzzocrea
Jan 1, 2018·Acta orthopaedica et traumatologica turcica·Dong-Yeong LeeDong-Hee Kim

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