PMID: 9182073Jan 1, 1997Paper

Pharmacological manipulation of human gastrointestinal blood flow

Fundamental & Clinical Pharmacology
C J Mathias

Abstract

The splanchnic circulation is one of the largest vascular regions in man. In the past, this has been difficult to study because of methodological problems. The adapting of noninvasive Doppler techniques has made it possible to develop reproducible measurements of coeliac and superior mesenteric artery blood flow, which are the main contributors to the gastrointestinal vasculature. This has resulted in the further understanding of neurogenic and humoral control of this region in a number of physiological and pathophysiological states, and has contributed towards the knowledge of its pharmacological control. These studies are of relevance to cardiovascular homeostasis and, in particular, systemic blood pressure control which depends upon various factors including responses in different vascular regions. In this review the key physiological factors which influence pharmacological studies on this circulation will be discussed. Examples will be provided, in subjects with cardiovascular and neurological disorders, of how administration of endogenous and exogenous substances, including drugs with specific pharmacological effects, alter human gastrointestinal blood flow. These will include insulin, alcohol, the somatostatin analogue oc...Continue Reading

References

Apr 1, 1977·Clinical Pharmacology and Therapeutics·J L ReidE Neill
Nov 1, 1992·The Journal of Physiology·K R ChaudhuriC J Mathias
Oct 1, 1991·Clinical Science·G D BraatvedtR J Corrall
Mar 1, 1991·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·K R ChaudhuriC J Mathias
Jun 1, 1991·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·E Armstrong, C J Mathias
Nov 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·M J StevensP J Watkins
Dec 1, 1989·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·J S KoonerC J Mathias
Jun 1, 1989·The Journal of Clinical Endocrinology and Metabolism·R D Hoeldtke, B C Israel
Jul 1, 1989·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·J S KoonerC J Mathias
Dec 22, 1986·The American Journal of Medicine·R D HoeldtkeT M O'Dorisio
Oct 1, 1988·Alimentary Pharmacology & Therapeutics·S D PringleD C Carter
Jul 18, 1987·British Medical Journal·C J MathiasR Bannister
Aug 29, 1987·British Medical Journal·G Williams, J C Pickup
Sep 12, 1987·British Medical Journal·R Jansen, W Hoefnagels
Nov 1, 1970·The American Journal of Physiology·J R McNeillC V Greenway
Mar 1, 1983·Clinical Science·T W MeadeW S Peart
Feb 1, 1995·British Journal of Anaesthesia·A UusaroJ Takala
May 1, 1993·British Journal of Clinical Pharmacology·K Ray-ChaudhuriC J Mathias
Sep 8, 1993·JAMA : the Journal of the American Medical Association·N MaynardI McColl
Apr 25, 1996·The New England Journal of Medicine·R K Goyal, I Hirano
Jul 1, 1996·British Journal of Anaesthesia·W L Biffl, E E Moore

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Citations

Nov 30, 2000·Critical Care : the Official Journal of the Critical Care Forum·G AcklandM G Mythen
Aug 24, 2002·Pediatric Research·Jane D CarverLewis A Barness
Sep 25, 2008·American Journal of Physiology. Endocrinology and Metabolism·Taila HartleyAllen Volchuk
May 25, 2004·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Birsen UnalSimay Kara

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