Pharmacological manipulation of the olfactory bulb modulates beta oscillations: testing model predictions

Journal of Neurophysiology
Bolesław L OsinskiLeslie M Kay

Abstract

The mammalian olfactory bulb (OB) generates gamma (40-100 Hz) and beta (15-30 Hz) local field potential (LFP) oscillations. Gamma oscillations arise at the peak of inhalation supported by dendrodendritic interactions between glutamatergic mitral cells (MCs) and GABAergic granule cells (GCs). Beta oscillations are induced by odorants in learning or odor sensitization paradigms, but their mechanism and function are still poorly understood. When centrifugal OB inputs are blocked, beta oscillations disappear, but gamma oscillations persist. Centrifugal inputs target primarily GABAergic interneurons in the GC layer (GCL) and regulate GC excitability, suggesting a causal link between beta oscillations and GC excitability. Our previous modeling work predicted that convergence of excitatory/inhibitory inputs onto MCs and centrifugal inputs onto GCs increase GC excitability sufficiently to produce beta oscillations primarily through voltage dependent calcium channel-mediated GABA release, independently of NMDA channels. We test some of the predictions of this model by examining the influence of NMDA and muscarinic acetylcholine (ACh) receptors, which affect GC excitability in different ways, on beta oscillations. A few minutes after int...Continue Reading

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Citations

Aug 6, 2019·Frontiers in Behavioral Neuroscience·Jordan M RossMax L Fletcher
Feb 2, 2020·Nature Communications·Behzad IravaniJohan N Lundström
Oct 17, 2020·Cerebral Cortex·Zihao ZhangJoost X Maier
Feb 20, 2021·Experimental Neurology·Rebeca Hernández-SotoFernando Peña-Ortega

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MATLAB File Exchange
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Chronux toolbox
MATLAB
Chronux
RmOB
MC Rack

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