Pharmacological modulation by celecoxib of cachexia associated with experimental arthritis and atherosclerosis in rabbits.

British Journal of Pharmacology
F I RomeroGabriel Herrero-Beaumont

Abstract

Non-steroidal anti-inflammatory drugs improve inflammatory cachexia in several conditions. Thus, we have explored inhibition of cyclooxygenase-2 (COX-2) in an experimental model of rheumatoid cachexia in rabbits. Chronic arthritis was induced in immunized rabbits by repeated intra-articular injections of ovalbumin. To increase the degree of systemic inflammation and also to induce atherosclerotic lesions, the animals were fed a hyperlipidaemic diet (2% cholesterol and 6% peanut oil) and were given an endothelial injury of the femoral artery. Rabbits were randomized to receive the COX-2 inhibitor celecoxib (10 mg·kg⁻¹ ·day⁻¹) or no treatment. After 4 weeks, sera, peripheral mononuclear cells and vessel specimens were collected. Inhibition of COX-2 by celecoxib modulated the systemic inflammatory response and increased total cholesterol and triglyceride levels. Celecoxib also minimized weight loss and prevented serum albumin fall. At a vascular level, celecoxib reduced COX-2 protein in the femoral arterial wall, but did not modify size or the macrophage infiltration of femoral lesions nor the percentage of rabbits with spontaneous aortic plaques. Our animal model induced a severe inflammatory cachexia, comparable to that of persi...Continue Reading

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Citations

Jan 4, 2012·Clinical and Experimental Pharmacology & Physiology·Ming ZhaoWei-Jin Zang
Jun 7, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Vikas DuttAshwani Mittal
Feb 15, 2019·Journal of Veterinary Pharmacology and Therapeutics·Jianzhong WangXingyuan Cao
Mar 22, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ana Belén Gómez-SanMiguelAsunción López-Calderón
May 10, 2018·Frontiers in Physiology·Sandra Pérez-BaosGabriel Herrero-Beaumont
Jul 26, 2017·Scientific Reports·Robert D LittleGabriel Herrero-Beaumont
Mar 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chao GongLianhua Chen

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