PMID: 3607373Jul 1, 1987

Pharmacological modulation of bronchial anaphylaxis induced by aerosol challenge in anaesthetized guinea-pigs

British Journal of Pharmacology
L DaffonchioB J Whittle

Abstract

Anaphylactic bronchoconstriction provoked by aerosol challenge, and its pharmacological modulation, has been investigated in anaesthetized pump-ventilated guinea-pigs actively sensitized to ovalbumin (OA). Aerosol challenge (OA 0.03-10 mg ml-1) provoked immediate bronchoconstriction, the degree of which, and its rate of development, was directly related to antigen concentration. Concomitant changes in heart rate and systemic arterial blood pressure following aerosol challenge were reduced compared with systemic (OA, 1 mg kg-1 i.v.) challenge. Unlike systemic challenge, aerosol challenge did not cause a concomitant fall in either circulating leukocyte or platelet count. When a submaximal (microshock) aerosol challenge stimulus (OA, 0.3 mg ml-1, 5 s) was employed, bronchoconstriction was markedly reduced by mepyramine (2 mg kg-1 i.v.). The residual component of bronchoconstriction was enhanced by indomethacin (10 mg kg-1 i.v.), an effect which was reversed by either BW755C (30 mg kg-1 i.v.) or FPL55712 (10 mg kg-1 i.v.). When a supramaximal (macroshock) aerosol challenge stimulus (OA, 10 mg ml-1, 5 s) was employed, bronchoconstriction was also markedly reduced by mepyramine. Residual bronchoconstriction was not altered by indomet...Continue Reading

References

Apr 12, 1989·European Journal of Pharmacology·C OminiL Daffonchio
Feb 28, 1989·European Journal of Pharmacology·L DaffonchioB J Whittle
Jan 7, 1992·European Journal of Pharmacology·S L UnderwoodD Raeburn
Jun 14, 2000·European Journal of Pharmacology·R PonsE J Morcillo
Jan 25, 2006·British Journal of Pharmacology·Sandra KeirClive Page
Jun 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H ArakawaB E Skoogh
May 20, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dedmer SchaafsmaHerman Meurs
Jul 1, 1988·British Journal of Pharmacology·L DaffonchioB J Whittle

Citations

Oct 1, 1979·Agents and Actions·K Forsberg, L Sörenby
Mar 1, 1987·Journal of Pharmacological Methods·A N Payne, G de Nucci
May 1, 1986·British Journal of Pharmacology·M F FitzgeraldL Parente
Aug 1, 1985·The Journal of Allergy and Clinical Immunology·C Robinson, S T Holgate
Jun 1, 1967·British Journal of Pharmacology and Chemotherapy·H O Collier, G W James
Jan 1, 1984·International Archives of Allergy and Applied Immunology·P Kallós, L Kallós
Jul 1, 1981·Agents and Actions·D M RitchieM E Rosenthale

Related Concepts

Allergens
Anesthesia Procedures
Lobar Bronchus Structure
Ovalbumin
Anaphylaxis
Aerosol Dose Form
Hemodynamics
Cavia porcellus
Respiratory Function Tests

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.