PMID: 8960387Aug 1, 1996Paper

Pharmacological modulation of spontaneous renal blood flow dynamics

Canadian Journal of Physiology and Pharmacology
D O AjikobiWilliam A Cupples

Abstract

Two mechanisms contribute to renal autoregulation. The faster system, which is thought to be myogenic, operates at 0.1-0.2 Hz (i.e., 5-10 s/cycle), while the slower one, tubuloglomerular feedback, operates at 0.03-0.05 Hz (i.e., 20-30 s/cycle). Both attenuate spontaneous or induced fluctuations of blood pressure, but it has proven difficult to separate their individual contributions because there is potential for interaction between the two. The present study was designed to examine the dynamics of the faster system during pharmacological blockade of tubuloglomerular feedback. Normotensive and hypertensive rats were studied under isoflurane or halothane anesthesia. Administration of the loop diuretic furosemide plus the angiotensin II (ANGII) AT1 receptor antagonist losartan caused a 10-fold or greater natriuresis, indicating profound inhibition of ascending limb salt transport, and also produced characteristic changes in the transfer function relating blood pressure (input) to renal blood flow (output). Operation of the 0.1-0.2 Hz mechanism was essentially unaltered, as shown by the presence of a peak in phase angle at 0.1-0.2 Hz and reduction of gain at frequencies slower than 0.15 Hz. The 0.03-0.05 Hz mechanism was markedly ...Continue Reading

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Citations

Dec 13, 2005·Annals of Biomedical Engineering·He ZhaoKi H Chon
Jul 20, 2012·Annals of Biomedical Engineering·Christopher G ScullyKi H Chon
Jan 5, 2002·The Journal of Physiology·Armin JustHartmut R Kirchheim
Mar 2, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·C Ichai, C Giunti
Jul 12, 2001·Advances in Therapy·L M Ruilope
Sep 23, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Armin Just
Jan 19, 2007·American Journal of Physiology. Renal Physiology·William A Cupples, Branko Braam
Dec 10, 1999·Canadian Journal of Physiology and Pharmacology·X WangW A Cupples
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
May 14, 2016·Bulletin of Mathematical Biology·Ioannis SgouralisAnita T Layton

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