Pharmacological MRI (phMRI) of the Human Central Nervous System

Clinical Neuroradiology
H LanfermannP Raab

Abstract

Pharmacological magnetic resonance imaging (phMRI) of the central nervous system (CNS) addresses the increasing demands in the biopharma industry for new methods that can accurately predict, as early as possible, whether novel CNS agents will be effective and safe. Imaging of physiological and molecular-level function can provide a more direct measure of a drug mechanism of action, enabling more predictive measures of drug activity. The availability of phMRI of the nervous system within the professional infrastructure of the Clinical Research Center (CRC) Hannover as proof of concept center ensures that advances in basic science progress swiftly into benefits for patients. Advanced standardized MRI techniques including quantitative MRI, kurtosis determination, functional MRI, and spectroscopic imaging of the entire brain are necessary for phMRI. As a result, MR scanners will evolve into high-precision measuring instruments for assessment of desirable and undesirable effects of drugs as the basic precondition for individually tailored therapy. The CRC's Imaging Unit with high-end large-scale equipment will allow the following unique opportunities: for example, identification of MR-based biomarkers to assess the effect of drugs (...Continue Reading

References

Nov 22, 2007·Clinical Pharmacology and Therapeutics·B G OertelJ Lötsch
Apr 22, 2008·Journal of Magnetic Resonance Imaging : JMRI·Xiao-Qi DingKurt Ullrich
Jan 7, 2011·Neurology·J J G GeurtsUNKNOWN MAGNIMS Study Group
Aug 5, 2011·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Xiao-Qi DingSusanne Petri
Apr 19, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dina Wittfoth-SchardtChristiane Waller
Jun 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Florian BeissnerVitaly Napadow
Aug 13, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 13, 2013·NeuroImage·Florian BeissnerKarl-Jürgen Bär
Feb 26, 2014·Current Opinion in Pharmacology·Paul M Matthews, Olivia C Geraghty
Mar 13, 2014·Frontiers in Human Neuroscience·Florian Beissner, Simon Baudrexel
Mar 29, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiao-Qi DingHeinrich Lanfermann
May 7, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sarah V BiedermannGabriele Ende
Dec 3, 2014·Psychiatry Research·Arpan DuttaJ F William Deakin
Dec 9, 2014·Alzheimer's Research & Therapy·Emilio Merlo PichWilliam Z Potter
Feb 13, 2015·Science Translational Medicine·Eugene P DuffStephen M Smith

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Citations

Apr 21, 2019·Acta neurochirurgica·Lucius FekonjaThomas Picht
May 28, 2019·The Journal of Headache and Pain·Jan HoffmannEdzard Wiener

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