PMID: 8950308Jan 1, 1996Paper

Pharmacological nature of TP receptor mediated contraction in human intrapulmonary artery

Life Sciences
H JinoS Temma

Abstract

The present experiments were undertaken to elucidate the pharmacological nature of thromboxane A2/prostaglandin H2 receptor (TP)-mediated contraction in human intrapulmonary arteries. 9,11-epithio-11, 12-methano-thromboxane A2 (STA2) and (15S)-hydroxy-9 alpha, 11 alpha-(epoxymethano) prosta-5Z, 13E-dienoic acid (U46619) (TXA2 agonists) caused contractions in a concentration-dependent manner with EC50 values of 1.4 x 10(-9) M and 3.1 x 10(-9) M, respectively. S-1452 and ONO-3708 (TP receptor antagonists) concentration-dependently attenuated the STA2 (10(-8) M)-induced contraction with IC50 values of 5.8 x 10(-9) M and 4.2 x 10(-8) M, respectively. U-73122 (3 x 10(-6) M) and 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate (3 x 10(-5) M) (phospholipase C inhibitors) significantly attenuated the STA2-induced contraction. Ca(+2)-induced contraction in the presence of STA2 (10(-8) M) in Ca(+2)-free medium was attenuated by nifedipine (10(-6) M) by 40%. The remaining nifedipine-resistant Ca(+2)-induced contraction was not attenuated by nitroglycerin (10(-5) M), but forskolin (10(-5) M) (adenylate cyclase stimulant) significantly decreased it by 75%. The results clearly indicate that in human intrapulmonary artery, there are TP receptors...Continue Reading

References

Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Sep 1, 1991·Medicinal Research Reviews·S E Hall
Jan 2, 1985·European Journal of Pharmacology·J Y JeremyP Dandona
May 18, 1984·European Journal of Pharmacology·T M Lincoln, V Fisher-Simpson
Nov 1, 1981·The American Journal of Physiology·R Loutzenhiser, C van Breemen
Apr 1, 1995·Journal of Applied Physiology·F IchinoseW M Zapol
Jan 1, 1995·Journal of Applied Physiology·D M LindeborgR G Pearl
Feb 1, 1995·Journal of Applied Physiology·S A KraftR G Pearl

❮ Previous
Next ❯

Citations

Jun 6, 2003·European Journal of Pharmacology·Wing Hung LauWui Hang Cheung
Dec 12, 2001·British Journal of Pharmacology·L WalchX Norel
Apr 27, 2002·British Journal of Pharmacology·Javier AnguloIñigo Sáenz De Tejada
Aug 19, 2003·British Journal of Pharmacology·Federico Manuel DarayRodolfo Pedro Rothlin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.