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Pharmacological potency of R- and S-3'-hydroxy-delta 9-tetrahydrocannabinol: additional structural requirement for cannabinoid activity

Pharmacology, Biochemistry, and Behavior

Jul 1, 1984

Berdine R MartinRaj K Razdan

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Abstract

The pharmacological potency of R- and S-3'-hydroxy-delta 9-tetrahydrocannabinol (THC) was compared to that of delta 9-THC as well as R/S-3'-OH-delta 9-THC. The S-isomer was found to be considerably more potent than the R-isomer in producing hypoactivity in mice, static-ataxia in dogs, a...read more

Mentioned in this Paper

Tremor
Discrimination (Process of Differentiation)
Canis familiaris
Ataxia
Dose-Response Relationship, Drug
Metazoa
Hypothermia, Natural
Structure-Activity Relationship
Ataxia as Late Effect of Cerebrovascular Disease
Cannabinoid [EPC]
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Pharmacological potency of R- and S-3'-hydroxy-delta 9-tetrahydrocannabinol: additional structural requirement for cannabinoid activity

Pharmacology, Biochemistry, and Behavior

Jul 1, 1984

Berdine R MartinRaj K Razdan

PMID: 6087379

DOI: 10.1016/0091-3057(84)90131-x

Abstract

The pharmacological potency of R- and S-3'-hydroxy-delta 9-tetrahydrocannabinol (THC) was compared to that of delta 9-THC as well as R/S-3'-OH-delta 9-THC. The S-isomer was found to be considerably more potent than the R-isomer in producing hypoactivity in mice, static-ataxia in dogs, a...read more

Mentioned in this Paper

Tremor
Discrimination (Process of Differentiation)
Canis familiaris
Ataxia
Dose-Response Relationship, Drug

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