Pharmacological preconditioning with intralipid in patients undergoing off-pump coronary artery bypass surgery.

Annals of Cardiac Anaesthesia
Gegal PruthiM Kurinchi Raja

Abstract

The objective of the study was to determine the preconditioning myocardial protective effects of intralipid (IL) in off-pump coronary artery bypass (OPCAB) surgery by measuring highly sensitive troponin T (hsTnT) and cardiac-specific creatine kinase (CK-MB) as markers of myocardial injury. : Thirty patients, scheduled to undergo elective OPCAB surgery, were randomly assigned to the IL group (n = 15) or control (C) group (n = 15); the IL group received an infusion of 20% IL 2 ml/kg, 30 min prior to revascularization and the control group received an equivalent volume of normal saline. Serum levels of hsTnT and CK-MB were measured before surgery and at 6 h, 24 h, 48 h, and 72 h postoperatively. Also, intraoperative hemodynamic parameters, inotrope use, ventilatory hours, ICU stay, postoperative left ventricular ejection fraction, postoperative lipid profile, renal and hepatic function tests were measured. The hsTnT values at the 24 h, 48 h, and 72 h in IL group were significantly lower as compared with the control group. The decline in plasma levels of CK-MB mirrored the hsTnT levels post revascularization at 24 h and 48 h in the IL group compared with the control group; however, at 72 h, level was comparable in both the groups. ...Continue Reading

References

Apr 29, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·O E DapuntU Mehlhorn
Jul 3, 1999·The Annals of Thoracic Surgery·N P WangJ Vinten-Johansen
Feb 24, 2001·The Annals of Thoracic Surgery·H B HanglerJ O Bonatti
Nov 25, 2004·Anesthesia and Analgesia·Viktoria D MayrHans-Ulrich Strohmenger
Sep 27, 2006·Circulation·Bernard L CroalBrian H Cuthbertson
Jun 28, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Sabzali Javadov, Morris Karmazyn
Feb 28, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Zhao-Yang HuJin Liu
Mar 7, 2009·Journal of Molecular and Cellular Cardiology·Andrew P Halestrap
Jun 10, 2011·Anesthesiology·Yoshitaka KawaraguchiHemal H Patel

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

MedCalc

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