Pharmacological preconditioning with resveratrol: role of CREB-dependent Bcl-2 signaling via adenosine A3 receptor activation

American Journal of Physiology. Heart and Circulatory Physiology
Samarjit DasDipak K Das

Abstract

Recent studies demonstrated that resveratrol, a grape-derived polyphenolic phytoalexin, provides pharmacological preconditioning (PC) of the heart through a NO-dependent mechanism. Because adenosine receptors play a role in PC, we examined whether they play any role in resveratrol PC. Rats were randomly assigned to groups perfused for 15 min with 1) Krebs-Henseleit bicarbonate buffer (KHB) only; 2) KHB containing 10 microM resveratrol; 3) 10 microM resveratrol + 1 microM 8-cyclopentyl-1,3-dimethylxanthine (CPT; adenosine A(1) receptor blocker); 4) 10 microM resveratrol + 1 microM 8-(3-chlorostyryl)caffeine (CSC; adenosine A(2a) receptor blocker); 5) 10 microM resveratrol + 1 microM 3-ethyl-5-benzyl-2-methyl-4-phenylethynyl-6-phenyl-1,4-(+/-)-dihydropyridine-3,5-dicarboxylate (MRS-1191; adenosine A(3) receptor blocker); or 6) 10 microM resveratrol + 3 microM 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride [LY-294002, phosphatidylinositol (PI)3-kinase inhibitor], and groups perfused with adenosine receptor blockers alone. Hearts were then subjected to 30-min ischemia followed by 2-h reperfusion. The results demonstrated significant cardioprotection with resveratrol evidenced by improved ventricular recovery and re...Continue Reading

References

Jan 1, 1995·Cardiovascular Research·D T EngelmanD K Das
Jan 1, 1995·Circulation Research·M B MitchellA Banerjee
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·B D GehmJ L Jameson
Nov 26, 1998·The Journal of Biological Chemistry·K Du, M Montminy
Jul 20, 1999·Molecular and Cellular Endocrinology·M Frödin, S Gammeltoft
Jul 23, 1999·Annals of the New York Academy of Sciences·R C Kukreja
Feb 19, 2000·Life Sciences·L Frémont
Jun 29, 2000·Annual Review of Biochemistry·A J Shaywitz, M E Greenberg
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·M SatoD K Das
Mar 13, 2001·Journal of Cardiovascular Pharmacology·L GiovanniniA Bertelli
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·E L KilpatrickR D Lasley
Jan 10, 2002·Cellular Signalling·Markus KlingerChristian Nanoff
Apr 23, 2002·Journal of Cellular Biochemistry·Qiang ZhangElaine Unemori
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Reiji HattoriDipak K Das
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Gembu ImamuraDipak K Das
Jun 14, 2002·European Journal of Pharmacology·Robert De JongeJan W De Jong
Jun 22, 2002·Annals of the New York Academy of Sciences·Buddhadeb Dawn, Roberto Bolli
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Helen L MaddockDerek M Yellon
Mar 26, 2003·European Journal of Pharmacology·Silvia BradamanteJan Willem De Jong
Jun 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Kazuo KatoJulie Chao
Jul 16, 2003·Clinical and Experimental Pharmacology & Physiology·Eleni VasaraAntigone Lazou
Oct 28, 2003·Molecular and Cellular Biochemistry·Ilan GoldenbergEhud Grossman

❮ Previous
Next ❯

Citations

Dec 14, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kenneth N GieddLynne L Johnson
May 13, 2009·Antioxidants & Redox Signaling·Shazib Pervaiz, Andrea Lisa Holme
Oct 3, 2012·Antioxidants & Redox Signaling·Ignazio BarbagalloGiovanni Li Volti
Sep 19, 2012·Metabolic Syndrome and Related Disorders·Yochai BirnbaumMandeep Bajaj
Feb 16, 2010·Thyroid : Official Journal of the American Thyroid Association·Hichem SebaiGuy Fayet
Dec 5, 2009·Cardiovascular Research·Narasimman GurusamyDipak K Das
Nov 4, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Iyyapu K MohanPeriannan Kuppusamy
Jul 12, 2011·Physiological Reviews·Mark A SussmanMichael McGregor
Apr 27, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Chun-Hsu PanChieh-Hsi Wu
Jun 13, 2015·Mediators of Inflammation·Jorge M BarciaFrancisco J Romero
May 6, 2016·Nutrients·Dominique Bonnefont-Rousselot
Sep 15, 2010·Molecular Aspects of Medicine·Manika Das, Dipak K Das
Mar 24, 2009·Free Radical Biology & Medicine·Elizabeth D Brookins DanzRebecca S Keller
Apr 4, 2013·The American Journal of Chinese Medicine·Wei-Tien ChangZuo-Hui Shao
Apr 27, 2016·Pharmacology & Therapeutics·Guanhua DuJuntian Zhang
Jun 1, 2005·Vascular Pharmacology·John P Headrick, Jason Peart
Dec 31, 2010·Dose-response : a Publication of International Hormesis Society·Subhendu MukherjeeDipak K Das
Apr 12, 2008·Purinergic Signalling·Stefania MerighiPier Andrea Borea
Nov 28, 2006·Journal of Cellular and Molecular Medicine·Karel BezstarostiDipak K Das
Jun 28, 2008·Apoptosis : an International Journal on Programmed Cell Death·Paula M BritoTeresa C P Dinis
Jan 9, 2009·Journal of Cardiovascular Pharmacology·Weimin YangChristopher J Wingard
Jun 13, 2009·Alcoholism, Clinical and Experimental Research·Lindsay BrownPeter Feick
Apr 29, 2010·Current Heart Failure Reports·Zhenggang Jiang, Mingdong Zhou
Mar 20, 2010·Heart Failure Reviews·Dipak K DasDiptarka Ray
Mar 9, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Yumei YeYochai Birnbaum
Mar 23, 2012·Journal of Bioenergetics and Biomembranes·Belma TuranGuy Vassort
May 3, 2012·Canadian Journal of Physiology and Pharmacology·Thomas Netticadan
May 20, 2017·Current Medicinal Chemistry·Luca LiberaleFederico Carbone
Mar 15, 2011·Heart Failure Reviews·Dipak K DasDiptarka Ray
Feb 21, 2019·Experimental and Therapeutic Medicine·Wenying WangYukun Luo
Jan 26, 2011·Annals of the New York Academy of Sciences·Goran PetrovskiDipak K Das
Oct 30, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Yumei YeYochai Birnbaum
Jan 26, 2011·Annals of the New York Academy of Sciences·Partha MukhopadhyayDipak K Das
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Naveet Pannu, Archana Bhatnagar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.