Pharmacological prevention of cardiovascular aging--targeting the Maillard reaction

British Journal of Pharmacology
Doron Aronson

Abstract

The development of myocardial and large vessel stiffness with aging underlies the development of diastolic heart failure and isolated systolic hypertension. Nonenzymatic reaction between glucose and proteins (Maillard reaction) leading to collagen crosslinking in the myocardium and arterial wall has been implicated in age-related increase in cardiovascular stiffness. In the present issue, Chang et al. show that aminoguanidine, an inhibitor of protein crosslinking, retards age-related decline in the elastic properties of the left ventricle and arteries. The significance of these findings is discussed in this commentary.

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Citations

Apr 6, 2012·Pharmacology & Therapeutics·Doron Aronson, Henry Krum
Jan 5, 2008·Journal of the American College of Cardiology·Grace Casaclang-VerzosaTeresa S M Tsang
Mar 25, 2015·Analytical Biochemistry·Julie BoucherMichel Grandbois
Jan 10, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·William B ErshlerEvan T Keller
Feb 8, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Julie BoucherMichel Grandbois
Apr 3, 2018·Chemical & Pharmaceutical Bulletin·Daisuke ImahoriTetsushi Watanabe
Aug 19, 2009·Chemical Research in Toxicology·Rena NishigakiKeiji Wakabayashi

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