PMID: 9660520Jul 11, 1998Paper

Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist

Blood Pressure. Supplement
P A van Zwieten

Abstract

This article reviews the pharmacological profile of the dihydropyridine calcium antagonist (CaA) barnidipine [(+)-(3'S,4S)-3-(1'-benzyl-3'-pyrrolidinyl)-methyl-2,6-dimethyl-4-(m-nit rophenyl)-1,4dihydropyridine-3,5-dicarboxylate x HCl]. The characteristics and potential advantages of its pharmacological selectivity are also outlined. Barnidipine is an L-type CaA with high affinity for [3H]nitrendipine binding sites (Ki = 0.21 nmol/l). Its pharmacological profile has been studied in a variety of isolated tissues and animal models, such as isolated coronary arteries (pig, dog, rat), aorta (guinea pig) and in hypertensive rats (spontaneously hypertensive, renal hypertensive, desoxycorticosterone acetate [DOCA]-salt). Barnidipine may be characterized as a highly potent drug with vasoselectivity and, accordingly, a lack of negative inotropic activity. The onset of its action in vivo is slow, and it does not elicit reflex tachycardia. Its long duration of action, due to its lipophilicity, means that satisfactory control of elevated blood pressure can be obtained with once-daily dosing. Another interesting feature of barnidipine is its stereoselectivity. As the barnidipine molecule contains two chiral centres, it can have four possibl...Continue Reading

References

Jan 1, 1983·Pharmacology & Therapeutics·A G Ellrodt, B N Singh
Oct 1, 1996·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·P A van Zwieten

❮ Previous
Next ❯

Citations

Jul 27, 2001·Current Hypertension Reports·F H LeenenB S Huang
Apr 21, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Inka HeinerAndreas Lückhoff
Aug 16, 2008·Archives of Pharmacal Research·Zekai HaliciElif Cadirci
Jul 25, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Itsuro KazamaMasahiro Tachi
Apr 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michiru Hirasawa, Quentin J Pittman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

© 2022 Meta ULC. All rights reserved