Pharmacological profile of nociceptin/orphanin FQ receptors

Clinical and Experimental Pharmacology & Physiology
G Calo'D Regoli

Abstract

1. Nociceptin/orphanin FQ (NC) and its receptor (OP4) represent a novel peptide/receptor system pharmacologically distinct from classical opioid systems. 2. Via OP4 receptor activation, NC regulates several biological functions, both at peripheral and central levels; therefore, the OP4 receptor may be viewed as a novel target for drug development. However, the pharmacology of this receptor is still in its infancy, with few molecules interacting selectively with this receptor. 3. In the present article, we review the findings of studies that have investigated the pharmacological profile of ligands selective for the OP4 receptor, these being two antagonists, the peptide [Nphe1]NC(1-13)NH2 and the non-peptide J-113397, and two agonists, the peptide [Arg14,Lys15]NC, and the non- peptide Ro 64-6198. 4. The results of these studies indicate that agents that selectively activate or block the OP4 receptor may represent new potential drugs for the treatment of human diseases.

References

Sep 5, 1996·European Journal of Pharmacology·G CalòD Regoli
Mar 7, 1998·British Journal of Pharmacology·R GuerriniD Regoli
Sep 7, 1999·Bioorganic & Medicinal Chemistry Letters·J WichmannF Jenck
Dec 23, 1999·European Journal of Pharmacology·A RizziD Regoli
Apr 1, 2000·British Journal of Pharmacology·G Calo'D Regoli
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·F JenckG Kilpatrick
May 12, 2000·British Journal of Pharmacology·S SbrennaC Bianchi
Jun 1, 2000·Naunyn-Schmiedeberg's Archives of Pharmacology·R BigoniD Regoli
Aug 15, 2000·European Journal of Pharmacology·M R CorbozJ A Hey
Sep 22, 2000·Peptides·M MassiD Regoli
Dec 1, 2000·Biochemical and Biophysical Research Communications·K OkadaY Shimohigashi
Dec 2, 2000·Journal of Medicinal Chemistry·H ShinkaiI Uchida
Feb 22, 2001·The Journal of Clinical Investigation·V LaudenbachP Gressens
Feb 24, 2001·Naunyn-Schmiedeberg's Archives of Pharmacology·A RizziG Calo'
Mar 17, 2001·British Journal of Pharmacology·R L McLeodJ A Hey
Apr 9, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C M Pastor, J L Frossard
Jun 1, 2001·Naunyn-Schmiedeberg's Archives of Pharmacology·D RizziG Calo
Dec 26, 2001·The Journal of Pharmacology and Experimental Therapeutics·Daniela RizziGirolamo Calo'
May 26, 2010·CNS Neuroscience & Therapeutics·Girolamo Calo'Remo Guerrini

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Citations

Feb 24, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Elaine C Gavioli, Girolamo Calo'
May 24, 2011·Journal of Molecular Neuroscience : MN·Rosalia CannarsaPatrizia Romualdi
Feb 6, 2004·European Journal of Pharmacology·Yukie KawaharaBen H C Westerink
Sep 3, 2003·Bioorganic & Medicinal Chemistry Letters·Zhengming ChenKenneth J Valenzano
Sep 9, 2004·BMC Neuroscience·Walaiporn TongjaroenbungamStefano O Casalotti
May 11, 2005·Expert Opinion on Investigational Drugs·Paul Neary, Conor P Delaney
Sep 23, 2008·Pharmacology, Biochemistry, and Behavior·Craig W StevensBrad W Stahlheber
Aug 8, 2007·Biomolecular Engineering·Yan YangZhiren Zhang
May 22, 2007·Neuropeptides·Scott M RawlsNurulain Zaveri
Apr 25, 2015·Behavioural Brain Research·Roberto Sebastián Miranda-Morales, Ricardo M Pautassi
Jul 12, 2005·CNS Drug Reviews·Girolamo CaloDomenico Regoli
Mar 20, 2004·Journal of Neurochemistry·Miwako KoizumiNiall P Murphy
May 19, 2009·European Journal of Pharmacology·Carmela FischettiGirolamo Calo'
Apr 24, 2003·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Susanne Meis
Feb 26, 2004·Bioorganic & Medicinal Chemistry Letters·Zhengming ChenDonald J Kyle
Mar 22, 2006·Journal of Peptide Science : an Official Publication of the European Peptide Society·Melinda LigetiAnna Magyar
Jun 7, 2005·The Journal of Pharmacology and Experimental Therapeutics·Victor Ruiz-VelascoAndrew D Sumner
Mar 14, 2020·Behavioural Pharmacology·Vicente Martínez, Raquel Abalo
Nov 24, 2004·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Sonja VuckovićSlobodan Milovanović
Sep 13, 2019·International Journal of Molecular Sciences·Gabriele Antonio ZingaleGiuseppe Grasso
Dec 27, 2003·World Journal of Gastroenterology : WJG·Ferenc SzalayKornelia Tekes

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