Pharmacological profile of the clonidine-induced inhibition of vasodepressor sensory outflow in pithed rats: correlation with alpha(2A/2C)-adrenoceptors.

British Journal of Pharmacology
Carlos M VillalónDavid Centurión

Abstract

Resistance blood vessels are innervated by sympathetic and primary sensory nerves, which modulate vascular tone through the release of noradrenaline and calcitonin gene-related peptide (CGRP), respectively. Moreover, electrical stimulation of the perivascular sensory outflow in pithed rats results in vasodepressor responses which are mainly mediated by CGRP release. The present study has investigated the role of alpha(2)-adrenoceptors in the inhibition of these vasodepressor responses. 144 pithed male Wistar rats were pretreated with hexamethonium (2 mg kg(-1) min(-1)) followed by i.v. continuous infusions of either methoxamine (15 and 30 microg kg(-1) min(-1)) or clonidine (3, 10 and 30 microg kg(-1) min(-1)). Under these conditions, electrical stimulation (0.56-5.6 Hz; 50 V and 2 ms) of the spinal cord (T(9)-T(12)) resulted in frequency-dependent decreases in diastolic blood pressure. The infusion of clonidine (10 microg kg(-1) min(-1)), as compared to those of methoxamine (15 or 30 microg kg(-1) min(-1)), inhibited the vasodepressor responses to electrical stimulation without affecting those to i.v. bolus injections of alpha-CGRP (0.1-1 microg kg(-1)). This inhibition by clonidine was: (i) antagonized by 300 microg kg(-1) ra...Continue Reading

References

Jan 1, 1978·Clinical and Experimental Hypertension : CHE·W Kobinger, L Pichler
Feb 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D B Bylund
May 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·N DeckerJ Schwartz
Aug 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·P B Timmermans, P A van Zwieten
Dec 27, 1996·European Journal of Pharmacology·K Gavin, J R Docherty
Oct 24, 1998·Trends in Pharmacological Sciences·R M EglenM P Dillon
Dec 16, 1998·European Journal of Pharmacology·J R Docherty
Jul 23, 1999·Annals of the New York Academy of Sciences·M GöthertG J Molderings
Sep 15, 2001·Nature·D Julius, A I Basbaum
Apr 1, 1995·American Journal of Therapeutics·Manuel Velasco, Augusta Luchsinger
Mar 1, 1964·Journal of Applied Physiology·L I KLEINMAN, E P RADFORD
Sep 1, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Stylianos TsakirisKleopatra H Schulpis
Feb 7, 2007·British Journal of Pharmacology·S P H AlexanderJ A Peters

❮ Previous
Next ❯

Citations

May 6, 2019·The Journal of Headache and Pain·Alejandro Labastida-RamírezAntoinette MaassenVanDenBrink
Aug 24, 2013·Basic & Clinical Pharmacology & Toxicology·Guadalupe Manrique-MaldonadoCarlos M Villalón
Jan 25, 2017·BioMed Research International·Abimael González-HernándezCarlos M Villalón
May 29, 2018·The Journal of Headache and Pain·Abimael González-HernándezCarlos M Villalón
Jan 23, 2016·Basic & Clinical Pharmacology & Toxicology·Inna Ruiz-SalinasCarlos M Villalón
Dec 4, 2020·Physiological Reviews·Christian AalkjærJo G R De Mey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.