Pharmacological profile of the receptors that mediate external carotid vasoconstriction by 5-HT in vagosympathectomized dogs

British Journal of Pharmacology
C M VillalónJ A Terrón

Abstract

1. 5-Hydroxytryptamine (5-HT) can produce vasodilatation or vasoconstriction of the canine external carotid bed depending upon the degree of carotid sympathetic tone. Hence, external carotid vasodilatation to 5-HT in dogs with intact sympathetic tone is primarily mediated by prejunctional 5-HT1-like receptors similar to the 5-HT1D subtype, which inhibit the carotid sympathetic outflow. The present investigation is devoted to the pharmacological analysis of the receptors mediating external carotid vasoconstriction by 5-HT in vagosympathectomized dogs. 2. Intracarotid (i.c.) infusions for 1 min of 5-HT (0.3, 1, 3, 10, 30 and 100 micrograms) resulted in dose-dependent decreases in both external carotid blood flow and the corresponding conductance; both mean arterial blood pressure and heart rate remained unchanged during the infusions of 5-HT. These responses to 5-HT were resistant to blockade by antagonists at 5-HT2 (ritanserin) and 5-HT3/5-HT4 (tropisetron) receptors, but were partly blocked by the 5-HT1-like and 5-HT2 receptor antagonist, methiothepin (0.3 mg kg-1); higher doses of methiothepin (1 and 3 mg kg-1) caused little, if any, further blockade. These methiothepin (3 mg kg-1)-resistant responses to 5-HT were not signific...Continue Reading

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Citations

Oct 7, 1998·European Journal of Pharmacology·C M VillalónJ A Terrón
Sep 24, 1998·Trends in Pharmacological Sciences·P R SaxenaC M Villalón
Jul 3, 2013·Expert Opinion on Pharmacotherapy·Martha B Ramírez RosasAntoinette Maassen Vandenbrink
May 12, 2006·Cephalalgia : an International Journal of Headache·U ArulmaniP R Saxena
Apr 29, 2003·Cephalalgia : an International Journal of Headache·E W WillemsP R Saxena
Jun 23, 2018·Cephalalgia : an International Journal of Headache·Dan LevyAntoinette MaassenVanDenBrink
May 30, 1997·Annals of the New York Academy of Sciences·C M VillalónJ A Terrón
May 3, 2008·Current Opinion in Neurology·Katharina Eikermann-Haerter, Michael A Moskowitz

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