Pharmacological properties of alpha-mangostin, a novel histamine H1 receptor antagonist

European Journal of Pharmacology
N ChairungsrilerdY Ohizumi

Abstract

In the isolated rabbit thoracic aorta and guinea-pig trachea, alpha-mangostin inhibited histamine-induced contractions in a concentration-dependent manner in the presence or absence of cimetidine, a histamine H2 receptor antagonist. But KCl-, phenylephrine- or carbachol-induced contractions were not affected by alpha-mangostin. The concentration-contractile response curve for histamine was shifted to the right in a parallel manner by alpha-mangostin. In the presence of chlorpheniramine, a histamine H1 receptor antagonist, alpha-mangostin did not affect the relaxation of the rabbit aorta induced by histamine. In the guinea-pig trachea, alpha-mangostin had no effect on the relaxation induced by dimaprit, a histamine H2 receptor agonist. alpha-Mangostin caused a concentration-dependent inhibition of the binding of [3H]mepyramine, a specific histamine H1 receptor antagonist to rat aortic smooth muscle cells. Kinetic analysis of [3H]mepyramine binding indicated the competitive inhibition by alpha-mangostin. These results suggest that alpha-mangostin is a novel competitive histamine H1 receptor antagonist in smooth muscle cells.

References

Apr 1, 1977·Journal of Medicinal Chemistry·W D JonesK T Stewart
May 2, 1991·European Journal of Pharmacology·T A Bökesoy, H O Onaran
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M YamashitaH Wada
Sep 1, 1991·Brain Research Bulletin·H WadaA Yamatodani
Nov 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H Behrendt, J Ring
Dec 1, 1988·Archives internationales de physiologie et de biochimie·M K KrstićZ S Katusić
Mar 29, 1989·European Journal of Pharmacology·N NakahataH Nakanishi
Apr 1, 1986·Circulation Research·S M SchwartzJ H Campbell
Aug 1, 1966·British Journal of Pharmacology and Chemotherapy·A S Ash, H O Schild
Aug 1, 1993·The Journal of Pharmacy and Pharmacology·D E Douglas

❮ Previous
Next ❯

Citations

May 25, 2012·Journal of Natural Medicines·Nuttavut KosemPrimchanien Moongkarndi
Sep 17, 2002·Biological & Pharmaceutical Bulletin·Keigo NakataniYasushi Ohizumi
Mar 24, 2009·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Veerachamy AlagarsamyHemant Kumar Sharma
Dec 6, 2008·Journal of Ethnopharmacology·Supinya TewtrakulWilawan Mahabusarakam
Aug 30, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·José Pedraza-ChaverriJazmin M Pérez-Rojas
Nov 21, 2018·Natural Product Research·Xiao-Qian ChiJun Zhou
May 26, 2007·Photodermatology, Photoimmunology & Photomedicine·Hiroaki MitaniChiharu Koide
Aug 9, 2007·Chemical Biology & Drug Design·V AlagarsamyT Durai Ananda Kumar
Nov 27, 2019·International Journal of Rheumatic Diseases·Xiaoqing ZhouZhaofeng Huang
Feb 20, 2016·International Journal of Oncology·Somchai KritsanawongRamida Watanapokasin
Aug 12, 2000·Journal of Enzyme Inhibition·C OkudairaK Umezawa
Jan 5, 2021·Royal Society Open Science·Jutamad BumrungSupason Wanichwecharungruang
Jan 12, 2021·Frontiers in Pharmacology·Natalie Vivien GunterSiau Hui Mah
Feb 20, 2021·European Journal of Pharmacology·Aihong YangRui Shen
Mar 16, 2006·Journal of Agricultural and Food Chemistry·Hyun-Ah JungA Douglas Kinghorn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.