PMID: 5919563Apr 1, 1966

Pharmacological properties of cholinoceptive neurones in the medulla and pons of the cat

The Journal of Physiology
P B BradleyJ H Wolstencroft

Abstract

1. Iontophoretic application of acetylcholine to neurones in the medulla and pons of the unanaesthetized decerebrate cat excited 35.5% and inhibited 22%. This was not a representative sample of lower brain stem neurones, since most penetrations were made medially. Some cholinoceptive neurones were in the medial reticular formation.2. The time course of the response to different doses has been described.3. Nicotine and nicotinic agents 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP) and choline phenyl ether (TM1) excited neurones excited by acetylcholine but, with one exception, did not inhibit neurones inhibited by acetylcholine.4. Muscarinic agents mimicked both the excitatory and inhibitory responses to acetylcholine. (+/-)-muscarine and bethanechol (beta-methylcholine carbamate) had a prolonged and powerful inhibitory action.5. Oxotremorine [1-(2-oxopyrrolidino)-4-pyrrolidino-butyne-2] had a long-lasting excitatory action on neurones excited by acetylcholine.6. Eserine and neostigmine potentiated the action of acetylcholine but in addition they had a strong excitatory effect on many brain stem neurones, independently of the action of acetylcholine.7. Excitatory and inhibitory responses to acetylcholine could be antagonized b...Continue Reading

Citations

Sep 1, 1983·Neuropharmacology·T Kubo, Y Misu
Jul 1, 1983·Neuropharmacology·P B Bradley, A P Lucy
Dec 1, 1973·Neuropharmacology·E B Kirsten, E P Schoener
Jan 1, 1973·Neuropharmacology·A BartoliniE F Domino
Jul 1, 1966·International Journal of Neuropharmacology·G L AvanzinoJ H Wolstencroft
May 1, 1968·International Journal of Neuropharmacology·U Schaeppi
May 1, 1966·British Journal of Pharmacology and Chemotherapy·G L AvanzinoJ H Wolstencroft
Feb 1, 1968·British Journal of Pharmacology and Chemotherapy·R LindmarE Muscholl
Jul 1, 1972·Respiration Physiology·L E McCarthy, H L Borison
Jan 1, 1967·Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie·T J Marczynski
Jan 1, 1986·Brain Research Bulletin·D B Beleslin, S K Krstić
Sep 1, 1983·Brain Research Bulletin·D B BeleslinS Dozić
Dec 1, 1981·Cellular and Molecular Neurobiology·R W Greene, D O Carpenter
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·J A Rosecrans, L T Meltzer
Apr 1, 1980·The International Journal of Neuroscience·C Torda
Aug 1, 1973·Experimental Neurology·A K Tebecis
May 1, 1989·British Journal of Addiction·J Grenhoff, T H Svensson
Oct 1, 1969·Brain Research·R J BoakesA Dray
Jun 1, 1972·British Journal of Pharmacology·P B Bradley, A Dray
Oct 29, 1986·Brain Research·P J Shiromani, D J McGinty
Jan 1, 1981·Pharmacology & Therapeutics·G H Hall
Mar 1, 1972·British Journal of Pharmacology·E Marley, T J Seller
Jul 1, 1974·British Journal of Pharmacology·E Marley, T J Seller
Jul 1, 1974·British Journal of Pharmacology·E Marley, T J Seller
Aug 1, 1976·British Journal of Pharmacology·P B Bradley, A Dray
Feb 14, 1979·Pflügers Archiv : European journal of physiology·N B Dev, H H Loeschcke
Jan 1, 1973·Pflügers Archiv : European journal of physiology·M Straschill, J Perwein
Jan 1, 1979·Journal of Neuroscience Research·J R ToleikisL L Boyarsky
Jan 1, 1987·Annals of Neurology·P A SibonyK A Manning
Mar 1, 1988·Annals of Neurology·P A SibonyK A Manning
Dec 24, 1966·Nature·P B BradleyG L Avanzino
Feb 1, 1971·British Journal of Pharmacology·J M Layman, A S Milton

Related Concepts

Acetylcholine Sulfate (1: 1)
Plant alkaloid
Atropen
Urecholine
Felis catus
Gallamine
Hexamethonium Compounds
Medulla Oblongata
Methacholine Compounds
Syntostigmine

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.