Pharmacological properties of protocatechuic Acid and its potential roles as complementary medicine

Evidence-based Complementary and Alternative Medicine : ECAM
Yoswaris SemamingNipon Chattipakorn

Abstract

This paper reviews the reported pharmacological properties of protocatechuic acid (PCA, 3,4-dihydroxy benzoic acid), a type of phenolic acid found in many food plants such as olives and white grapes. PCA is a major metabolite of anthocyanin. The pharmacological actions of PCA have been shown to include strong in vitro and in vivo antioxidant activity. In in vivo experiments using rats and mice, PCA has been shown to exert anti-inflammatory as well as antihyperglycemic and antiapoptotic activities. Furthermore, PCA has been shown to inhibit chemical carcinogenesis and exert proapoptotic and antiproliferative effects in different cancerous tissues. Moreover, in vitro studies have shown PCA to have antimicrobial activities and also to exert synergistic interaction with some antibiotics against resistant pathogens. This review aims to comprehensively summarize the pharmacological properties of PCA reported to date with an emphasis on its biological properties and mechanisms of action which could be therapeutically useful in a clinical setting.

References

Jan 1, 1997·Frontiers in Bioscience : a Journal and Virtual Library·C A Feghali, T M Wright
Jan 1, 2003·Medical & Biological Engineering & Computing·J Zhou-StacheA K Bosserhoff
Jan 23, 2003·Journal of Agricultural and Food Chemistry·Marja P Kähkönen, Marina Heinonen
May 10, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Z Sroka, W Cisowski
Oct 7, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alejandra Ester RotelliLilian Eugenia Pelzer
Oct 31, 2003·Expert Reviews in Molecular Medicine·Aedin CassidyGerald Rimbach
Apr 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Julie R JonesMark A Magnuson
Dec 24, 2005·The New England Journal of Medicine·David M NathanUNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research
Jun 30, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S GuanL J An
Dec 15, 2006·Nature·Evan D Rosen, Bruce M Spiegelman
Feb 17, 2007·International Journal of Cancer. Journal International Du Cancer·Hui-Hsuan LinChau-Jong Wang
Apr 6, 2007·International Journal of Experimental Pathology·Toby Lawrence, Derek W Gilroy
Aug 21, 2007·Phytotherapy Research : PTR·Wen-hu LiuMei-chin Yin
Aug 21, 2007·Seminars in Cell & Developmental Biology·Anne M Manicone, John K McGuire
Aug 22, 2007·Neuroscience Letters·Andrea TarozziPatrizia Hrelia
Aug 22, 2007·The Journal of Nutrition·Paola VitaglioneVincenzo Fogliano
Jun 5, 2008·Journal of Agricultural and Food Chemistry·Lisbeth A Pacheco-PalenciaStephen T Talcott
Jul 16, 2008·International Journal of Food Microbiology·Mei-chin Yin, Che-yi Chao
Sep 16, 2008·The Journal of Nutritional Biochemistry·Maria Garcia-AlonsoSonia de Pascual-Teresa
Dec 20, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Shui GuanZhan-Feng Cui
Dec 23, 2008·Foodborne Pathogens and Disease·Che-Yi Chao, Mei-Chin Yin
Mar 28, 2009·International Journal of Molecular Sciences·Massimo D'ArchivioClaudio Giovannini
May 6, 2009·Molecular Nutrition & Food Research·Colin D KayAedin Cassidy
May 20, 2009·Journal of Ethnopharmacology·Victor KueteBonaventure Tchaleu Ngadjui
Nov 3, 2009·Biological & Pharmaceutical Bulletin·Hong-Ning ZhangXiao-Ping Pu
Dec 23, 2009·The International Journal of Biochemistry & Cell Biology·Toby Lawrence, Carol Fong
Feb 26, 2010·Mediators of Inflammation·Hideaki KanetoTaka-aki Matsuoka
Mar 5, 2010·The New England Journal of Medicine·Elizabeth SelvinFrederick L Brancati
Mar 20, 2010·Current Aging Science·Brannon L Queen, Trygve O Tollefsbol
Mar 23, 2010·Cell·Ruslan Medzhitov
Apr 28, 2010·Journal of Alzheimer's Disease : JAD·David A PattenRuth S Slack
Jun 15, 2010·Environmental and Molecular Mutagenesis·Michelle Barbi de MouraBennett Van Houten
Oct 20, 2010·The British Journal of Nutrition·Javier González-GallegoMaría J Tuñón
Oct 27, 2010·Journal of Natural Products·Tzung-Han ChouChia-Hua Liang

❮ Previous
Next ❯

Citations

Nov 6, 2015·Phytotherapy Research : PTR·Tochukwu J N OkonkwoPeter Proksch
Jan 23, 2016·Molecular Nutrition & Food Research·Iveta NajmanováPřemysl Mladěnka
Oct 27, 2016·British Journal of Pharmacology·Bo-Wen LinYing-Yu Cui
Mar 16, 2017·Journal of Medicinal Food·Adriana Rivera-PizaSung-Joon Lee
Oct 12, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sherif T S Hassan, Emil Švajdlenka
Apr 27, 2018·Acta Pharmacologica Sinica·Zhuo-Ming LiPei-Qing Liu
Feb 20, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Meran Keshawa EdiriweeraSameera Ranganath Samarakoon
Feb 8, 2020·Biomolecules·Mariam AbotalebDietrich Büsselberg
Jun 15, 2018·International Journal of Molecular Medicine·Yun-Yun GuanXiaoyan Shen
Jul 8, 2019·Journal of Basic and Clinical Physiology and Pharmacology·Olorunfemi R MolehinKehinde A Idowu
Jan 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hosam O ElansaryHalina Ekiert
Jul 22, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Duygu Yesim DikmenNurcan Bektas
Oct 28, 2019·Critical Reviews in Food Science and Nutrition·Iveta NajmanováPřemysl Mladěnka
Mar 25, 2019·AAPS PharmSciTech·Manoj Kumar GautamRenu Chadha
Dec 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kawintra TamprasitJintanaporn Wattanathorn
Aug 29, 2018·Oxidative Medicine and Cellular Longevity·Seon-A JangSe Chan Kang
Jun 20, 2020·Critical Reviews in Food Science and Nutrition·Raffaella Colombo, Adele Papetti
Dec 13, 2019·Journal of Agricultural and Food Chemistry·Jianhui LiuZhen-Yu Chen
Mar 2, 2021·Drug and Chemical Toxicology·Solomon E OwumiAdegboyega K Oyelere
Jun 19, 2021·Critical Reviews in Food Science and Nutrition·Yunxiao GaoYilin You
Jun 23, 2021·Critical Reviews in Food Science and Nutrition·Soon-Sen LeowRavigadevi Sambanthamurthi

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Postȩpy higieny i medycyny doświadczalnej
B Olas, B Wachowicz
Archivum Immunologiae Et Therapiae Experimentalis
Roman PaduchJan Fiedurek
© 2022 Meta ULC. All rights reserved