Pharmacological protection of hearing loss in the mouse model of endolymphatic hydrops

The Laryngoscope
Sami J MelkiCliff A Megerian

Abstract

Excitotoxic and related inflammatory injury are implicated in the spiral ganglion degeneration seen with Meniere's disease and endolymphatic hydrops (ELH). Excitotoxicity is initiated with glutamate elevation and associated with downstream increases in reactive oxygen species resulting in inflammation-mediated neuronal degeneration. This study tests the hypothesis that interruption of the initial and/or downstream aspects of excitotoxicity should provide hearing protection in ELH-associated hearing loss. This study tests whether riluzole, a glutamate release inhibitor, and dimethylsulfoxide (DMSO), an anti-inflammatory and antioxidant solvent with favorable properties at the level of glutamate receptors, can protect against early-stage hearing loss in a mouse model of ELH. The Phex(Hyp-Duk) mouse spontaneously develops ELH and postnatal hearing loss. Starting at postnatal day 6 (P6), daily injections of riluzole + DMSO or just DMSO were administered. Untreated mutants served as controls. At P21, P25, and P30, hearing function was assessed by recording auditory brainstem responses. A cochlear function index was developed to assess global cochlear function at each time point. Compared to no treatment, DMSO provided significant he...Continue Reading

References

Feb 2, 1995·The New England Journal of Medicine·S C Manolagas, R L Jilka
Mar 3, 1994·The New England Journal of Medicine·S A Lipton, P A Rosenberg
Jul 14, 2000·Acta Oto-laryngologica·L NordangM Anniko
May 1, 2002·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Joe C Adams
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ritsuko Katoh-SembaKanefusa Kato
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·Sten OrreniusPierluigi Nicotera
Mar 20, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Bettina Lorenz-DepiereuxEva M Eicher
Aug 4, 2004·European Journal of Pediatrics·Gadi FishmanUri S Alon
Feb 9, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Saumil N MerchantJoseph B Nadol
Jun 24, 2005·Neuroreport·Jerôme RuelJean Luc Puel
Aug 5, 2006·Hearing Research·Q Y ZhengK N Alagramam
Nov 3, 2006·Hearing Research·Jérôme RuelJean-Luc Puel
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
May 1, 2007·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Samantha AnneCliff A Megerian
Jul 20, 2007·Arthritis Research & Therapy·Brendan F Boyce, Lianping Xing
Feb 22, 2008·Hearing Research·Cliff A MegerianKumar N Alagramam
Aug 5, 2008·Lancet·Hamed Sajjadi, Michael M Paparella
Jan 31, 2009·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Anthony A MikulecAlec N Salt

❮ Previous
Next ❯

Citations

Oct 22, 2011·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Suhael R MominCliff A Megerian
Feb 11, 2014·Journal of the Association for Research in Otolaryngology : JARO·Sami J MelkiKumar N Alagramam
Oct 14, 2014·Current Otorhinolaryngology Reports·Cameron C WickCliff A Megerian
Mar 13, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·A Roldán-FidalgoR Ramírez-Camacho
Oct 11, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Laurel M FisherRick A Friedman
May 25, 2015·Hearing Research·Linlin YangFengchan Han
Apr 14, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Shanshan HuangFengchan Han
Feb 28, 2019·Orphanet Journal of Rare Diseases·Signe Sparre Beck-NielsenOuti Mäkitie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Suhael R MominCliff A Megerian
Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Carol A Foster, Robert E Breeze
Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Laurel M FisherRick A Friedman
© 2021 Meta ULC. All rights reserved