Pharmacological rescue of nociceptive hypersensitivity and oxytocin analgesia impairment in a rat model of neonatal maternal separation

Pain
Meggane MelchiorPierrick Poisbeau

Abstract

Oxytocin (OT), known for its neurohormonal effects around birth, has recently been suggested for being a critical determinant in neurodevelopmental disorders. This hypothalamic neuropeptide exerts a potent analgesic effect through an action on the nociceptive system. This endogenous control of pain has an important adaptive value but might be altered by early life stress, possibly contributing to its long-term consequences on pain responses and associated comorbidities. We tested this hypothesis using a rat model of neonatal maternal separation (NMS) known to induce long-term consequences on several brain functions including chronic stress, anxiety, altered social behavior, and visceral hypersensitivity. We found that adult rats with a history of NMS were hypersensitive to noxious mechanical/thermal hot stimuli and to inflammatory pain. We failed to observe OT receptor-mediated stress-induced analgesia and OT antihyperalgesia after carrageenan inflammation. These alterations were partially rescued if NMS pups were treated by intraperitoneal daily injection during NMS with OT or its downstream second messenger allopregnanolone. The involvement of epigenetic changes in these alterations was confirmed since neonatal treatment with...Continue Reading

References

Mar 8, 2000·Progress in Neurobiology·J F HerreroJ A López-García
Aug 17, 2001·Developmental Psychobiology·V LovicA S Fleming
Apr 17, 2002·The Journal of Physiology·D A RobinsonM Zhuo
Apr 15, 2003·Journal of Behavioral Medicine·Peter SalmonJonathan Rhodes
Nov 12, 2003·Archives of Pediatrics & Adolescent Medicine·C Celeste JohnstonAnnie Veilleux
May 26, 2005·Journal of Child Sexual Abuse·Colin A Ross
Jul 5, 2005·Nature Reviews. Neuroscience·Maria Fitzgerald
Aug 6, 2005·AACN Clinical Issues·Susan M Ludington-HoeDeborah L Torowicz
Jan 18, 2006·The Journal of Pain : Official Journal of the American Pain Society·Oliva Erendira Luis-DelgadoFrançois Lasbennes
Apr 20, 2006·Seminars in Fetal & Neonatal Medicine·Sinno H P Simons, Dick Tibboel
May 9, 2008·Frontiers in Neuroendocrinology·Frances A Champagne
Oct 30, 2008·Molecular Psychiatry·C HeimC B Nemeroff
Aug 6, 2009·Handbook of Experimental Pharmacology·Jyoti N Sengupta
Apr 13, 2010·Behavioural Brain Research·Megan L Uhelski, Perry N Fuchs
Jun 18, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ara Schorscher-PetcuJeffrey S Mogil
Oct 5, 2010·Psychopharmacology·Siobhain M O'MahonyJohn F Cryan
Aug 23, 2011·Stress : the International Journal on the Biology of Stress·Chris Murgatroyd, Dietmar Spengler
Dec 31, 2011·Hormones and Behavior·Meera E Modi, Larry J Young
May 21, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chen-Hwan CherngChih-Shung Wong
Sep 21, 2013·Annual Review of Psychology·C Sue Carter
Oct 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pierre-Eric JuifPierrick Poisbeau
Nov 21, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·V Théodorou
Feb 6, 2014·The European Journal of Neuroscience·Fred Schwaller, Maria Fitzgerald
Jul 6, 2014·Frontiers in Cellular Neuroscience·Pierrick PoisbeauMichael Schumacher
Feb 24, 2015·Science·Larry J Young, Catherine E Barrett

❮ Previous
Next ❯

Citations

Feb 21, 2019·Journal of Neuroendocrinology·Tatsushi Onaka, Yuki Takayanagi
Jun 12, 2020·Physiological Reviews·Rohini Kuner, Thomas Kuner
Apr 20, 2019·Frontiers in Psychology·Manuela FilippaPierre Kuhn
Feb 23, 2021·The European Journal of Neuroscience·Meggane MelchiorPierrick Poisbeau
Oct 30, 2021·Journal of Neuroendocrinology·Tatsushi Onaka, Yuki Takayanagi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.