Pharmacological research in pediatrics: From neonates to adolescents

Advanced Drug Delivery Reviews
Natella Y Rakhmanina, J N van den Anker

Abstract

The data guiding the dosing, efficacy and safety of medicines for children have lagged substantially as compared to the information available for adults. As a consequence, pediatricians faced with the prospect of confining their practice to medicines with adequate information have frequently resorted to prescribing medicines for unapproved uses (different dose, frequency, age group, route, indication or formulation). Although a long time in coming, the past decade, have witnessed a new era in drug development for children--an era that is still in its infancy, but which is currently showing signs of maturation. This review will give some of the history and current progress in pharmacological research and pediatric drug development.

Citations

Jan 12, 2012·International Journal of Clinical Pharmacy·S Suna OguzUgur Dilmen
Apr 13, 2010·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care·Isabella De GiorgiPascal Bonnabry
Jul 25, 2007·Antimicrobial Agents and Chemotherapy·Anouk E MullerJohn N van den Anker
Nov 13, 2013·Paediatric Drugs·Chris StockmannCatherine M T Sherwin
Mar 17, 2010·Expert Review of Clinical Pharmacology·Steven E Kern
Nov 25, 2011·Expert Review of Clinical Pharmacology·Karel Allegaert, John van den Anker
May 1, 2008·Expert Review of Clinical Pharmacology·Karel AllegaertGunnar Naulaers
Feb 4, 2014·Drug Development and Industrial Pharmacy·Areeg Anwer AliDaud Baraka Abdallah
Dec 23, 2006·Expert Opinion on Drug Delivery·Jörg Breitkreutz, Joachim Boos
Aug 19, 2007·Expert Opinion on Pharmacotherapy·Elke H J KrekelsOscar E Della Pasqua
Feb 16, 2011·Expert Opinion on Drug Metabolism & Toxicology·Amy E Mercer, Mariama Sarr Sallah
Feb 2, 2016·Drug Metabolism Reviews·Petra MatalováPavel Anzenbacher
Aug 11, 2015·British Journal of Clinical Pharmacology·Kate O'HaraJennifer H Martin
Oct 6, 2012·Pediatric Clinics of North America·Natella Rakhmanina, B Ryan Phelps
May 18, 2011·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Anne Smits, Karel Allegaert
Jul 4, 2015·Clinical Pharmacokinetics·Frederique RodieuxMarc Pfister
Sep 28, 2007·Paediatric Anaesthesia·Karel AllegaertIsabelle Murat
Dec 4, 2008·Fundamental & Clinical Pharmacology·Luc Zimmer
Apr 5, 2008·Acta Clinica Belgica·K AllegaertJ de Hoon
Nov 28, 2012·International Journal of Clinical Practice. Supplement·J N van den Anker
Oct 29, 2010·Developmental Disabilities Research Reviews·Johannes N van den Anker
Sep 24, 2015·BMC Pediatrics·Julie A MennellaDanielle R Reed
Nov 12, 2014·Antimicrobial Agents and Chemotherapy·Susanna E Medellín-GaribayEmilia Barcia
Aug 17, 2016·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Roberta Maia de Castro RomanelliPaulo Augusto Moreira Camargos
May 16, 2014·Shock·Milica BajčetićIvan Spasojević
Oct 30, 2007·British Journal of Anaesthesia·K AllegaertC A Knibbe
Feb 3, 2010·Pharmaceuticals·Karel AllegaertMarc Gewillig
Nov 28, 2013·Pharmaceuticals·Gian Maria Pacifici
May 29, 2018·Expert Opinion on Drug Metabolism & Toxicology·Paul Malik, Andrea Edginton
Sep 25, 2018·Journal of Clinical Pharmacology·John van den AnkerGregory L Kearns
Oct 3, 2013·The Journal of Rheumatology·Femke H M Prince, Daniel H Solomon
Jun 22, 2010·European Journal of Epidemiology·François AngoulvantCorinne Alberti
Apr 16, 2019·The Clinical Journal of Pain·Ernest A Kopecky
Apr 6, 2012·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Cuneyt TaymanKarel Allegaert
Apr 8, 2021·International Journal of Hypertension·Wafa' J AabedNaser Y Shraim

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