Pharmacological responses of human and porcine lung parenchyma, bronchus and pulmonary artery

British Journal of Pharmacology
R G GoldieJ L Wale


1 Responses of preparations of human and porcine isolated bronchus and pulmonary artery to carbachol (CCh), methacholine, histamine, 5-hydroxytryptamine (5-HT), (-)-noradrenaline (NA), (-)adrenaline (Adr) and (+/-)-isoprenaline (Iso) were compared with responses to the same agonists in isolated lung parenchyma strips. 2 All preparations from both human and porcine lung contracted in response to histamine and all, except preparations of porcine pulmonary artery, contracted in response to CCh. Human and porcine pulmonary artery and parenchyma strip contracted in response to NA while bronchial preparations invariably relaxed. Iso caused relaxation of human and porcine bronchus and parenchyma strip. Although 5-HT was completely inactive in tissues isolated from pig lung, this amine was a powerful spasmogen in human pulmonary artery, relaxed human bronchus and caused variable responses in human parenchyma. 3 Results indicate that the pharmacological characteristics of human and porcine parenchyma strips may be explained in terms of responses of vascular or airways smooth muscle.


Feb 15, 1979·European Journal of Pharmacology·H W Mitchell, M A Denborough
Jun 1, 1978·The Journal of Clinical Investigation·J M Drazen, M W Schneider
Jan 1, 1974·CRC Critical Reviews in Biochemistry·T D Pollard, R R Weihing
May 1, 1971·Journal of Applied Physiology·H J Colebatch, C A Mitchell


May 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·E Glusa, M Richter
Dec 1, 1985·Agents and Actions·P O Ogunbiyi, P Eyre
Nov 27, 1984·European Journal of Pharmacology·C A Gruetter, S M Lemke
Jul 23, 1987·European Journal of Pharmacology·A G Driver, S J Mustafa
May 17, 1991·European Journal of Pharmacology·P Schoeffter, T Godfraind
Dec 7, 1993·European Journal of Pharmacology·A F RoffelJ Zaagsma
Jan 1, 1990·Pharmacology & Therapeutics·R G GoldieK M Lulich
Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·R G GoldieJ W Paterson
Nov 1, 1993·Journal of Pharmacological and Toxicological Methods·A R Hulsmann, J C de Jongste
Aug 26, 1998·Respiration Physiology·J Van de Voorde, G Joos
Mar 24, 1998·General Pharmacology·B DestaC M Boulanger
Mar 28, 2003·Respiratory Physiology & Neurobiology·José Henrique Leite-JúniorWalter A Zin
Jun 1, 1991·British Journal of Pharmacology·P Ellis, E Müller-Schweinitzer
Nov 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·C J van KoppenC A van Ginneken
Sep 1, 1985·Journal of Pharmacological Methods·J C de JongsteK F Kerrebijn
Jan 1, 1988·Experimental Lung Research·J L Szarek, J N Evans
Jul 15, 2015·European Journal of Pharmacology·Fatma AydinogluNuran Ogulener
May 1, 1985·British Journal of Pharmacology·M J FinneyC G Persson
Jan 1, 1989·Pharmacology & Toxicology·P Schoeffter, T Godfraind
Oct 1, 1985·British Journal of Pharmacology·C Advenier, J L Freslon
Dec 1, 1983·British Journal of Pharmacology·P S FosterD Spina
Sep 1, 1984·British Journal of Pharmacology·Julio CortijoM Perpiñá
Apr 1, 1984·British Journal of Pharmacology·R G GoldieJ L Wale
Feb 1, 1983·British Journal of Pharmacology·P S FosterJ W Paterson
Sep 1, 1983·British Journal of Pharmacology·J F BertramJ W Paterson
Oct 24, 2018·The Journal of Experimental Biology·Daniel García-PárragaAndreas Fahlman
Feb 1, 1984·Acta Pharmacologica Et Toxicologica·E MikkelsenL T Jespersen
Oct 12, 1999·Journal of Applied Physiology·F PetákP D Sly
Jul 9, 1998·Journal of Applied Physiology·F G Salerno, M S Ludwig
Jul 1, 1989·British Journal of Pharmacology·D SpinaR G Goldie
May 1, 1983·British Journal of Pharmacology·R G GoldieJ L Wale

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