Abstract
Vasopressors are frequently given in hemodynamically unstable patients with severe Candida sepsis. While catecholamines can aggravate sepsis-induced immune dysfunction and modulate bacterial virulence traits, their impact on fungal pathogenicity is poorly understood. Using IncuCyte time-lapse microscopy and a fruit fly candidiasis model, we studied growth rates, morphogenesis, stress tolerance, and virulence of C. albicans cocultured with epinephrine and norepinephrine. We found that pharmacologically attainable catecholamine serum concentrations caused minimal changes to in vitro growth kinetics, filamentation, and fungal resistance to thermal or oxidative stress. Similarly, exposure of C. albicans to catecholamines did not alter the survival of infected flies.
References
Mar 1, 1995·Intensive Care Medicine·J BoldtG Hempelmann
Oct 31, 1997·Journal of the American Academy of Dermatology·B J WilliamsM Bartlett
Sep 17, 1998·Journal of the American Academy of Dermatology·E Epstein
Jul 4, 2001·Trends in Microbiology·R A Calderone, W A Fonzi
Mar 7, 2006·The Journal of Infectious Diseases·Georgios ChamilosDimitrios P Kontoyiannis
Jun 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marcie B ClarkeVanessa Sperandio
Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Apr 9, 2008·Journal of Bacteriology·Mark T Anderson, Sandra K Armstrong
Sep 25, 2008·FEMS Microbiology Reviews·Chaoyang XueJoseph Heitman
Aug 21, 2009·Critical Care : the Official Journal of the Critical Care Forum·Enrico CalziaPeter Radermacher
Jan 25, 2012·Medical Mycology·Patrícia Albuquerque, Arturo Casadevall
Apr 21, 2012·International Journal of Microbiology·Georgios HamilosDimitrios P Kontoyiannis
Jun 17, 2015·Critical Care Medicine·Ashraf FawzyAllan J Walkey
Jul 12, 2016·American Journal of Respiratory and Critical Care Medicine·Roeland F StolkMatthijs Kox
Oct 1, 2016·Journal of Clinical Anesthesia·Ozgun Cuvas ApanAlparslan Apan
Feb 22, 2017·Metallomics : Integrated Biometal Science·Gaurav BairwaJames W Kronstad
Apr 15, 2019·Microbial Pathogenesis·Emmanuel Konadu SarkodieWeihua Chu
May 30, 2019·MBio·Sebastian WursterDimitrios P Kontoyiannis