Pharmacological serum concentrations of epinephrine and norepinephrine do not affect growth rate, morphogenesis, stress tolerance, and virulence of Candida albicans.

Medical Mycology
Sebastian WursterDimitrios P Kontoyiannis

Abstract

Vasopressors are frequently given in hemodynamically unstable patients with severe Candida sepsis. While catecholamines can aggravate sepsis-induced immune dysfunction and modulate bacterial virulence traits, their impact on fungal pathogenicity is poorly understood. Using IncuCyte time-lapse microscopy and a fruit fly candidiasis model, we studied growth rates, morphogenesis, stress tolerance, and virulence of C. albicans cocultured with epinephrine and norepinephrine. We found that pharmacologically attainable catecholamine serum concentrations caused minimal changes to in vitro growth kinetics, filamentation, and fungal resistance to thermal or oxidative stress. Similarly, exposure of C. albicans to catecholamines did not alter the survival of infected flies.

References

Oct 31, 1997·Journal of the American Academy of Dermatology·B J WilliamsM Bartlett
Sep 17, 1998·Journal of the American Academy of Dermatology·E Epstein
Jul 4, 2001·Trends in Microbiology·R A Calderone, W A Fonzi
Jun 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marcie B ClarkeVanessa Sperandio
Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Apr 9, 2008·Journal of Bacteriology·Mark T Anderson, Sandra K Armstrong
Sep 25, 2008·FEMS Microbiology Reviews·Chaoyang XueJoseph Heitman
Aug 21, 2009·Critical Care : the Official Journal of the Critical Care Forum·Enrico CalziaPeter Radermacher
Jan 25, 2012·Medical Mycology·Patrícia Albuquerque, Arturo Casadevall
Apr 21, 2012·International Journal of Microbiology·Georgios HamilosDimitrios P Kontoyiannis
Jul 12, 2016·American Journal of Respiratory and Critical Care Medicine·Roeland F StolkMatthijs Kox
Oct 1, 2016·Journal of Clinical Anesthesia·Ozgun Cuvas ApanAlparslan Apan
Feb 22, 2017·Metallomics : Integrated Biometal Science·Gaurav BairwaJames W Kronstad
Apr 15, 2019·Microbial Pathogenesis·Emmanuel Konadu SarkodieWeihua Chu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

© 2021 Meta ULC. All rights reserved