Pharmacological studies of antigen-induced arthritis in BALB/c mice. I. Characterization of the arthritis and the effects of steroidal and non-steroidal anti-inflammatory agents

Agents and Actions
I M HunneyballM Spowage

Abstract

Chronic monoarticular allergic arthritis was induced in BALB/c mice using methylated BSA as antigen and Freund's complete adjuvant, together with Bordetella pertussis as a secondary adjuvant. The optimum conditions for induction of chronic persistent arthritis and the histological characteristics of the arthritic lesion are described. Both the synovitis and erosive progression of the arthritis could be suppressed by daily treatment with prednisolone (1-10 mg/kg) or dexamethasone (0.5-2.5 mg/kg) for 4 weeks commencing 2 weeks after the induction of arthritis. In contrast, daily treatment with the non-steroidal anti-inflammatory agents ibuprofen (50-100 mg/kg), flurbiprofen (1-9 mg/kg) or indomethacin (0.1-3 mg/kg) had no significant effect on either the synovitis or erosions as judged histologically. Synovial fluid differential leukocyte counts were altered by treatment with ibuprofen and indomethacin but not by flurbiprofen or the corticosteroids. The suppressive effect of the corticosteroids was not due to either suppression of antibody synthesis or alteration of the number of leukocytes in the peripheral circulation.

References

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Citations

Jan 1, 1992·Agents and Actions·G W Cannon, D S Harper
Feb 13, 2003·Experimental Gerontology·Hiroshi IwaiSusumu Ikehara
Jan 1, 1999·Bioorganic & Medicinal Chemistry Letters·S T SchlachterR A Nugent
Aug 17, 2005·International Immunopharmacology·Lilly GanjuRamesh Chandra Sawhney
Jun 1, 2016·Biochemical and Biophysical Research Communications·Keisuke ImadaTakashi Sato
Jun 15, 1999·Toxicologic Pathology·A BendeleM Guy
Feb 20, 2004·Pharmacoepidemiology and Drug Safety
Jan 1, 1988·Scandinavian Journal of Rheumatology. Supplement·B J de VriesL B van de Putte

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