PMID: 10367Oct 1, 1976

Pharmacological studies with adenine, adenosine and some phosphorylated derivatives on guinea-pig tracheal muscle

The Journal of Pharmacy and Pharmacology
J B Farmer, D G Farrar


Adenine, adenosine and three adenine nucleotides all caused relaxation of the guinea-pig trachea. The relaxation to the nucleotides was often preceded by a contraction. The response to adenosine and the nucleotides, but not adenine, was potentiated by dipyridamole. Imidazole inhibited the response to adenine alone. Propranolol has no effect on the response to any of the compounds. It is concluded that the guinea-pig trachea does not possess and a nucleotide-specific receptor as has been postulated for some other smooth muscle preparations. An alternative hypothesis postulating an adenosine-specific receptor is presented.


May 1, 1973·The American Journal of Physiology·R F Coburn, T Tomita
Oct 1, 1974·British Journal of Pharmacology·R A Coleman, G P Levy
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Jan 1, 1971·European Journal of Pharmacology·N KolassaM Träm
Nov 1, 1966·British Journal of Pharmacology and Chemotherapy·A Stafford


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Nov 13, 1990·European Journal of Pharmacology·S M Stoggall, J S Shaw
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Dec 1, 1980·British Journal of Pharmacology·J Christie, D G Satchell
May 1, 1985·British Journal of Pharmacology·M J FinneyC G Persson
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Dec 1, 1983·British Journal of Pharmacology·Y Bach-DieterleA F Junod
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