PMID: 10367Oct 1, 1976

Pharmacological studies with adenine, adenosine and some phosphorylated derivatives on guinea-pig tracheal muscle

The Journal of Pharmacy and Pharmacology
J B Farmer, D G Farrar

Abstract

Adenine, adenosine and three adenine nucleotides all caused relaxation of the guinea-pig trachea. The relaxation to the nucleotides was often preceded by a contraction. The response to adenosine and the nucleotides, but not adenine, was potentiated by dipyridamole. Imidazole inhibited the response to adenine alone. Propranolol has no effect on the response to any of the compounds. It is concluded that the guinea-pig trachea does not possess and a nucleotide-specific receptor as has been postulated for some other smooth muscle preparations. An alternative hypothesis postulating an adenosine-specific receptor is presented.

References

May 1, 1973·The American Journal of Physiology·R F Coburn, T Tomita
Oct 1, 1974·British Journal of Pharmacology·R A Coleman, G P Levy
Jan 1, 1970·The Journal of Pharmacy and Pharmacology·J B Farmer, R A Coleman
Mar 1, 1971·The Journal of Pharmacy and Pharmacology·R A Coleman, J B Farmer
Jan 1, 1971·European Journal of Pharmacology·N KolassaM Träm
Nov 1, 1966·British Journal of Pharmacology and Chemotherapy·A Stafford

Citations

Sep 11, 1981·European Journal of Pharmacology·J Chapal, M M Loubatieres-Mariani
Jan 8, 1985·European Journal of Pharmacology·I Alexander, P Eyre
Jun 24, 1986·European Journal of Pharmacology·N A Darmani, K J Broadley
Nov 13, 1990·European Journal of Pharmacology·S M Stoggall, J S Shaw
Sep 7, 1987·Life Sciences·G GhaiM F Hopkins
May 1, 1989·The Journal of Allergy and Clinical Immunology·N CrimiA Mistretta
Aug 1, 1992·British Journal of Pharmacology·J R Thorne, K J Broadley
Aug 1, 1987·The American Review of Respiratory Disease·R A Pauwels, M E Van der Straeten
Dec 1, 1980·British Journal of Pharmacology·J Christie, D G Satchell
May 1, 1985·British Journal of Pharmacology·M J FinneyC G Persson
Jul 1, 1982·British Journal of Pharmacology·C M Brown, M G Collis
Dec 1, 1983·British Journal of Pharmacology·Y Bach-DieterleA F Junod
Feb 1, 1983·British Journal of Clinical Pharmacology·M J CushleyS T Holgate
Nov 1, 1988·British Journal of Pharmacology·L A Welford, W H Anderson
Aug 14, 2012·Pharmacological Reviews·Geoffrey BurnstockJean-Pierre Timmermans
Sep 1, 1984·Acta Pharmacologica Et Toxicologica·K A LundbladC G Persson
Sep 1, 1984·British Journal of Pharmacology·L CaparrottaR M Gaion
Feb 1, 1988·British Journal of Pharmacology·C AdvenierE Naline

Related Concepts

Adenine
Adenocard
Novo-Dipiradol
Cavia porcellus
Imidazoles
Novodrin
Inotropism
Smooth Muscle
Rexigen
Quinidex

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