PMID: 3755114Apr 1, 1986Paper

Pharmacological study of nicergoline. (II). Protective effect on ischemic brain damages in animals

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
K ShintomiY Matsuoka

Abstract

Effects of nicergoline on ischemic brain damages induced by bilateral carotid arterial ligation (BCAL) in ICR-strain mice and mongolian gerbils and lipid peroxide formation (LPOF) in normal brain homogenate of rats were compared with those of dihydroergotoxine (DHE). In mice, nicergoline (16 mg/kg, i.p.) significantly reduced the cumulative mortality rate after BCAL (from 80-83% in the control to 50-55%). In gerbils, nicergoline (32 mg/kg, i.p.) significantly prolonged the mean onset time of ischemic seizure following recirculation after the 30-min BCAL (from 45.8 min in the control to 94.9 min). DHE also showed protective effects in these animals. In the ischemic brain of mice, marked decreases of creatine-P, ATP, glucose and glycogen; a remarkable increase of lactate; and elevation of L/P ratio were observed 1 to 10 min after BCAL. Nicergoline (16 mg/kg, i.p.) slightly prevented these decreases and significantly suppressed the increase of lactate and the elevation of L/P ratio 2 min after BCAL. The inhibitory action of nicergoline (20-100 microM) on LPOF is more potent than those of alpha-tocopherol and DHE. These results suggest that nicergoline may have protective effects against ischemic brain damages due to its ameliorati...Continue Reading

Citations

Aug 1, 1990·British Journal of Pharmacology·K Takahashi, N Akaike
Jun 10, 2004·Biological & Pharmaceutical Bulletin·Atsushi NishidaHitoshi Endou
Mar 19, 1999·European Journal of Pharmacology·M VairettiF Bertè
Oct 24, 2002·European Journal of Pharmacology·Mariapia VairettiPlinio Richelmi
Nov 24, 2004·European Journal of Pharmacology·Mariapia VairettiPlinio Richelmi

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