Pharmacological synergism of bee venom and melittin with antibiotics and plant secondary metabolites against multi-drug resistant microbial pathogens

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Issam Al-AniMichael Wink

Abstract

The goal of this study was to investigate the antimicrobial activity of bee venom and its main component, melittin, alone or in two-drug and three-drug combinations with antibiotics (vancomycin, oxacillin, and amikacin) or antimicrobial plant secondary metabolites (carvacrol, benzyl isothiocyanate, the alkaloids sanguinarine and berberine) against drug-sensitive and antibiotic-resistant microbial pathogens. The secondary metabolites were selected corresponding to the molecular targets to which they are directed, being different from those of melittin and the antibiotics. The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) were evaluated by the standard broth microdilution method, while synergistic or additive interactions were assessed by checkerboard dilution and time-kill curve assays. Bee venom and melittin exhibited a broad spectrum of antibacterial activity against 51 strains of both Gram-positive and Gram-negative bacteria with strong anti-MRSA and anti-VRE activity (MIC values between 6 and 800 µg/ml). Moreover, bee venom and melittin showed significant antifungal activity (MIC values between 30 and 100 µg/ml). Carvacrol displayed bactericidal activity, while BITC exhibited bacteriosta...Continue Reading

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Citations

Jul 29, 2016·World Journal of Microbiology & Biotechnology·Barış Gökalsın, Nüzhet Cenk Sesal
Aug 29, 2016·Toxicon : Official Journal of the International Society on Toxinology·Alessandra Daniele-SilvaMatheus F Fernandes-Pedrosa
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Jan 16, 2018·Drug Discoveries & Therapeutics·Rinrampai PuttipanSiriporn Okonogi
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Aug 28, 2018·Bioconjugate Chemistry·Li LuoGui-Xue Wang

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