Pharmacological targeting of spreading depression in migraine.

Expert Review of Neurotherapeutics
Katharina Eikermann-HaerterCenk Ayata

Abstract

Migraine, particularly with aura, is a genetically heterogeneous disorder of ion channels, pumps or transporters associated with increased cortical excitability. Spreading depression, as one reflection of hyperexcitability, is the electrophysiological event underlying aura symptoms and a trigger for headache. Endogenous (e.g., genes and hormones) and exogenous factors (e.g., drugs) modulating migraine susceptibility have also been shown to modulate spreading depression susceptibility concordantly, suggesting that spreading depression can be a relevant therapeutic target in migraine. In support of this, several migraine prophylactic drugs used in clinical practice have been shown to suppress spreading depression susceptibility as a probable mechanism of action, despite belonging to widely different pharmacological classes. Hence, susceptibility to spreading depression can be a useful preclinical model with good positive and negative predictive value for drug screening.

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Citations

Oct 26, 2014·Brain : a Journal of Neurology·Dennis A Turner
Jun 11, 2014·Headache·Katharina Eikermann-Haerter
Dec 10, 2015·Pain·Shih-Pin ChenCenk Ayata
Mar 20, 2015·Pain·Else A TolnerArn M J M van den Maagdenberg
Dec 11, 2014·DNA and Cell Biology·Raffaele PalmirottaFiorella Guadagni
Mar 30, 2016·Current Opinion in Neurology·Andrew Charles, Amynah A Pradhan
May 25, 2016·Current Pain and Headache Reports·Shih-Pin Chen, Cenk Ayata
May 8, 2016·Cephalalgia : an International Journal of Headache·Shih-Pin ChenKatharina Eikermann-Haerter
May 15, 2013·Cephalalgia : an International Journal of Headache·Cenk Ayata
Jul 25, 2013·The Journal of Headache and Pain·Cinzia CostaPaola Sarchielli
Jan 20, 2018·Neurological Research·Piet Borgdorff
Aug 27, 2017·Headache·Shih-Pin Chen, Cenk Ayata
Feb 10, 2018·Cerebral Cortex·David Y ChungCenk Ayata
Apr 22, 2017·Brain : a Journal of Neurology·Shih-Pin ChenKatharina Eikermann-Haerter
May 3, 2019·The Journal of Headache and Pain·Andrea M HarriottShih-Pin Chen
May 11, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Paolo BazzigaluppiBojana Stefanovic

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