PMID: 18431035Apr 24, 2008Paper

Pharmacological topics of bone metabolism: recent advances in pharmacological management of osteoporosis

Journal of Pharmacological Sciences
Atsushi SuzukiMitsuyasu Itoh

Abstract

The prevention of osteoporotic fracture is an essential socioeconomical priority, especially in the developed countries including Japan. Estrogen, selective estrogen-receptor modulators (SERMs), and bisphosphonate are potent inhibitors of bone resorption; and they have clinical relevance to reduce osteoporotic fractures in postmenopausal women. However, we can prevent at most 50% of vertebral fractures with these agents. For the better compliance of aminobisphosphonate, the use of a daily bisphosphonate regimen is moving to a weekly or monthly bisphosphonate regimen. Both cathepsin K inhibitors and modulators of the RANK-RANKL system, which can reduce bone resorption, are the candidates for the future treatment of osteoporosis. As well as bone resorption, we need to increase bone formation to prevent osteoporotic fractures, particularly in elderly patients with low bone turnover. In the U.S., Europe, and Australia, they have already started intermittent parathyroid hormone injection and/or oral strontium ranelate to stimulate bone formation. We still need to discover new agents to reduce osteoporotic fractures for the better quality of life without fractures.

References

Dec 1, 1995·International Journal of Epidemiology·P D RossL J Melton
Jul 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S FujiwaraK Kodama
Jul 31, 1999·Science·J D NorrisD P McDonnell
Jun 13, 2001·JAMA : the Journal of the American Medical Association·D J Torgerson, S E Bell-Syer
Nov 1, 2001·The Cochrane Database of Systematic Reviews·A CranneyG Wells
Aug 31, 2002·Endocrine Reviews·Ann CranneyUNKNOWN Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group
Aug 31, 2002·Endocrine Reviews·Ann CranneyUNKNOWN Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group
Oct 2, 2003·JAMA : the Journal of the American Medical Association·Jane A CauleyUNKNOWN Women's Health Initiative Investigators
Mar 19, 2004·The New England Journal of Medicine·Henry G BoneUNKNOWN Alendronate Phase III Osteoporosis Treatment Study Group
Apr 8, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Min Pi, L Darryl Quarles
Dec 23, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Jennifer A KnoppBrian H Rowe
Mar 4, 2005·Treatments in Endocrinology·Manuel Muñoz-TorresMezquita Pedro Raya
Mar 8, 2005·Journal of Bone and Mineral Metabolism·Yasunaga OnoMitsuyasu Itoh
May 11, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Susan B JaglalJonathan D Adachi
Jul 12, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Paul D MillerCyrus Cooper
Dec 27, 2005·Current Topics in Medicinal Chemistry·David N Deaton, Francis X Tavares
Apr 26, 2006·The Journal of Clinical Endocrinology and Metabolism·Mark E MolitchPatricia A Stephens
May 25, 2006·The Journal of Clinical Endocrinology and Metabolism·Shalender BhasinVictor M Montori
Jun 1, 2006·The Journal of Clinical Endocrinology and Metabolism·Catherine M JankowskiWendy M Kohrt
Jun 7, 2006·JAMA : the Journal of the American Medical Association·Victor G VogelUNKNOWN National Surgical Adjuvant Breast and Bowel Project (NSABP)
Jun 28, 2006·Archives of Internal Medicine·Sarah CockayneDavid J Torgerson
Jul 14, 2006·The New England Journal of Medicine·Elizabeth Barrett-ConnorUNKNOWN Raloxifene Use for The Heart (RUTH) Trial Investigators
Sep 23, 2006·Expert Opinion on Biological Therapy·E Michael Lewiecki
Oct 5, 2006·The Journal of Clinical Endocrinology and Metabolism·Margaret E WiermanNanette Santoro
Dec 28, 2006·JAMA : the Journal of the American Medical Association·Dennis M BlackUNKNOWN FLEX Research Group
Feb 20, 2007·Annals of the New York Academy of Sciences·S TournisG P Lyritis
May 4, 2007·The New England Journal of Medicine·Dennis M BlackUNKNOWN HORIZON Pivotal Fracture Trial
Aug 1, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sundeep KhoslaUNKNOWN American Society for Bone and Mineral Research
Aug 22, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E Michael LewieckiUNKNOWN AMG 162 Bone Loss Study Group
Aug 31, 2007·The Journal of Sexual Medicine·Abdulmaged TraishUNKNOWN Testosterone Therapy in Women Study Group

❮ Previous
Next ❯

Citations

Feb 4, 2010·Future Medicinal Chemistry·Izabela Podgorski
Feb 27, 2009·Nutrition Research Reviews·Anna TrzeciakiewiczMarie-Noëlle Horcajada
Sep 3, 2009·Current Osteoporosis Reports·Jean-Yves ReginsterOlivier Bruyere
May 6, 2009·Clinical and Experimental Pharmacology & Physiology·Mahmoud M El-Mas, Abdel A Abdel-Rahman
Jun 3, 2015·Journal of Pharmacological Sciences·Haruka EmoriKatsuji Oguchi
Feb 24, 2015·Journal of Pharmacological Sciences·Tai-Yong YuGong-She Yang
Feb 3, 2018·European Journal of Clinical Investigation·Lucía Melguizo-RodríguezOlga García-Martínez
Aug 15, 2012·Nature Reviews. Rheumatology·Christos E LampropoulosDavid P D'Cruz
Nov 6, 2010·Expert Opinion on Pharmacotherapy·Jean-Yves Reginster, Audrey Neuprez
Jun 1, 2010·Therapeutic Advances in Musculoskeletal Disease·Jean-Yves ReginsterOlivier Bruyere
Feb 28, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ismail SolmazMusa Karakukcu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Best Practice & Research. Clinical Obstetrics & Gynaecology
Tobias Johannes de Villiers
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Ego SeemanJean-Yves Reginster
© 2022 Meta ULC. All rights reserved