PMID: 18431038Apr 24, 2008Paper

Pharmacological topics of bone metabolism: antiresorptive microbial compounds that inhibit osteoclast differentiation, function, and survival

Journal of Pharmacological Sciences
Je-Tae WooKazuo Nagai

Abstract

The mass and function of bones depends on the maintenance of a complicated balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Osteoporosis typically reflects an imbalance in skeletal turnover, such that bone resorption exceeds bone formation. Osteoclasts are target cells for anti-osteoporosis therapies. To discover new types of antiresorptive agents, we screened for natural compounds that regulate osteoclast differentiation, function, and survival. As a result, we identified reveromycin A, destruxins, mevastatin, FK506, cyclosporin A, prodigiosins, concanamycins, and symbioimine among microbial natural compounds. In this review, we discuss the mechanisms of action of these compounds on osteoclasts.

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Citations

Aug 3, 2010·Rheumatology International·Pooneh Salari SharifBagher Larijani
Sep 25, 2012·Joint, Bone, Spine : Revue Du Rhumatisme·Pietro Enea LazzeriniFranco Laghi-Pasini
Oct 5, 2010·Seminars in Arthritis and Rheumatism·Pietro Enea LazzeriniFranco Laghi-Pasini
Mar 11, 2015·Journal of Cellular Biochemistry·Brittany MeadDaniel Jones
Jun 3, 2015·Journal of Pharmacological Sciences·Haruka EmoriKatsuji Oguchi
Nov 15, 2011·Biotechnology Advances·Bing-Lan Liu, Yew-Min Tzeng
Nov 1, 2011·Biochemical and Biophysical Research Communications·Chonnaree WisutsitthiwongTanapat Palaga
Dec 2, 2017·Periodontology 2000·Brian Henderson, Frank Kaiser
Oct 18, 2019·Molecular and Cellular Biochemistry·Anureet Kaur Shah, Hoda Yeganehjoo
Mar 18, 2016·Clinical and Experimental Dental Research·Xianqi LiHideaki Kagami
Nov 9, 2019·The Journal of Organic Chemistry·Ichiro HayakawaAkira Sakakura

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