Pharmacological treatment of comorbid PTSD and substance use disorder: recent progress

Addictive Behaviors
Mehmet SofuogluIsmene L Petrakis

Abstract

Previous research has identified a strong association between posttraumatic stress disorder (PTSD) and substance use disorder (SUD), necessitating the development of treatments that address both conditions. Some pharmacotherapies are effective for the treatment of PTSD and SUD alone, however; no medications have been proven to be effective for the combination of these conditions. We review the recent advances in pharmacological treatment of comorbid PTSD and SUD. A randomized clinical trial of sertraline, a serotonin reuptake inhibitor (SSRI), did not show overall efficacy for comorbid PTSD and alcohol dependence (AD), although it may have efficacy among light drinkers. Another clinical trial demonstrated the efficacy of both disulfiram and naltrexone for the treatment of AD in individuals with PTSD. A more recent clinical trial suggested that norepinephrine uptake inhibitors may also have efficacy for the treatment of comorbid PTSD and AD. In animal and preliminary human studies, brain norepinephrine and glutamate/GABA have emerged as potential treatment targets for comorbid PTSD and SUD. Noradrenergic medications that are promising for comorbid PTSD and SUD include prazosin, guanfacine, and atomoxetine. Promising glutamate/GA...Continue Reading

References

Aug 6, 2014·Alcoholism, Clinical and Experimental Research·Steven L BatkiEllen Herbst
Apr 2, 2015·Alcoholism, Clinical and Experimental Research·Tracy L SimpsonAndrew J Saxon
Jun 10, 2016·Current Psychiatry Reports·Julianne C FlanaganSudie E Back
Oct 18, 2016·Genes, Brain, and Behavior·N W Gilpin, J L Weiner
Jan 20, 2017·Alcoholism, Clinical and Experimental Research·Ismene L Petrakis, Tracy L Simpson
Mar 25, 2014·Trends in Neurosciences·Dan P CoveyPaul A Garris
Jan 21, 2015·The Cochrane Database of Systematic Reviews·Jonathan C IpserDan J Stein
Feb 24, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yann S MineurMarina R Picciotto
Jul 12, 2019·Frontiers in Behavioral Neuroscience·Nathaniel P StaffordSergios Charntikov
Jan 30, 2016·Molecular Psychiatry·C Garcia-KellerP W Kalivas
Jul 24, 2019·International Journal of Molecular Sciences·Arturo AndradeLaura Londrigan
Feb 24, 2016·Journal of Addiction Medicine·Ganesh GopalakrishnaMarina A Nemetalla
Jan 30, 2019·Academic Psychiatry : the Journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·Katherine A Kosman, Nomi C Levy-Carrick

Citations

Jan 1, 1995·Journal of Traumatic Stress·D D BlakeT M Keane
May 29, 1999·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·J Chick
Feb 25, 2000·Biological Psychiatry·R M BermanJohn H Krystal
May 30, 2001·Drug and Alcohol Dependence·Mehmet SofuogluDorothy K Hatsukami
Aug 2, 2001·The American Journal of Psychiatry·L K JacobsenThomas Kosten
Aug 29, 2001·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·A Gual, P Lehert
May 11, 2002·Behaviour Research and Therapy·A van MinnenG P J Keijsers
Mar 14, 2003·Drug and Alcohol Dependence·Mehmet SofuogluDorothy K Hatsukami
Dec 20, 2003·Annals of the New York Academy of Sciences·David A BakerP W Kalivas
Feb 16, 2005·Annual Review of Physiology·Evangelia CharmandariGeorge Chrousos
Mar 17, 2005·Alcoholism, Clinical and Experimental Research·Kathleen T BradyKit Simpson
Aug 2, 2005·The American Journal of Psychiatry·Kathleen T Brady, Rajita Sinha
Sep 30, 2006·Biological Psychiatry·Ismene L PetrakisBruce Rounsaville
Nov 23, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Pascale MardikianRobert Malcolm
Dec 8, 2006·The American Journal of Psychiatry·Thomas C NeylanCharles R Marmar
Mar 3, 2007·The American Journal of Psychiatry·Evgeny M KrupitskyJohn H Krystal
Jul 31, 2007·Psychiatry·Matthew A BattistaSiobhan O'Toole
Oct 11, 2007·JAMA : the Journal of the American Medical Association·Bankole A JohnsonTopiramate for Alcoholism Study Group
Jan 25, 2008·Alcoholism, Clinical and Experimental Research·Martin DriessenTRAUMAB-Study Group
Apr 11, 2008·The Journal of Trauma·Laura L McGheeIan H Black
Jul 11, 2008·Neuron·George F Koob
Jul 16, 2008·The Journal of Nervous and Mental Disease·Alan Fontana, Robert Rosenheck
Sep 25, 2008·Addiction Biology·Mehmet Sofuoglu, R Andrew Sewell
Oct 4, 2008·Journal of Psychopharmacology·C ChiamuleraG Fumagalli
Dec 24, 2008·Biological Psychiatry·Lori A KnackstedtP W Kalivas
Apr 1, 2009·Brain Research·Lakshmi N Ravindran, Murray B Stein
Apr 2, 2009·The Annals of Pharmacotherapy·Christopher P AldermanJudith R Fuller
Dec 9, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Suzanne Erb
Dec 18, 2009·The American Journal of Drug and Alcohol Abuse·Mehmet SofuogluThomas Kosten
Nov 11, 2010·The Annals of Pharmacotherapy·Thomas L SchwartzAnne Costello

Related Concepts

Topiramate
Biological Adaptation to Stress
Central Nervous System Stimulant [EPC]
Laboratory Studies
Serotonin Reuptake Inhibitor [EPC]
Central Nervous System Stimulants
Dual Diagnosis (Psychiatry)
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Depressed - Symptom
Post-Traumatic Stress Disorder

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