Pharmacological treatment of increased vascular risk and cognitive performance in middle-aged and old persons: six-year observational longitudinal study

BMC Neurology
Marlise E A van EerselGerbrand J Izaks

Abstract

Lowering vascular risk is associated with a decrease in the prevalence of cardiovascular disease and dementia. However, it is still unknown whether lowering of vascular risk with pharmacological treatment preserves cognitive performance in general. Therefore, we compared the change in cognitive performance in persons with and without treatment of vascular risk factors. In this longitudinal observational study, 256 persons (mean age, 58 years) were treated for increased vascular risk during a mean follow-up period of 5.5 years (treatment group), whereas 1678 persons (mean age, 50 years) did not receive treatment (control group). Cognitive performance was three times measured during follow-up using the Ruff Figural Fluency Test (RFFT) and Visual Association Test (VAT), and calculated as the average of standardized RFFT and VAT score per participant. Because treatment allocation was nonrandomized, additional analyses were performed in demographic and vascular risk-matched samples and adjusted for propensity scores. In the treatment group, mean (SD) cognitive performance changed from - 0.30 (0.80) to - 0.23 (0.80) to 0.02 (0.87), and in control group, from 0.08 (0.77) to 0.24 (0.79) to 0.49 (0.74) at the first, second and third mea...Continue Reading

References

Feb 12, 1998·Annals of Internal Medicine·D B Rubin
Oct 11, 2002·Archives of Internal Medicine·Françoise ForetteUNKNOWN Systolic Hypertension in Europe Investigators
Nov 30, 2002·Lancet·James ShepherdUNKNOWN PROSPER study group. PROspective Study of Pravastatin in the Elderly at Risk
Dec 14, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Paul E de JongDick de Zeeuw
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Jun 10, 2008·The New England Journal of Medicine·Anushka PatelFlorence Travert
Sep 9, 2008·American Journal of Epidemiology·Hiddo J Lambers HeerspinkUNKNOWN PREVEND Study Group
May 7, 2009·JAMA : the Journal of the American Medical Association·Bakhtawar K MahmoodiUNKNOWN Prevention of Renal and Vascular End-stage Disease (PREVEND) Study Group
Sep 18, 2010·BMC Neuroscience·Claudia BartelsHannelore Ehrenreich
Sep 23, 2010·Vascular Health and Risk Management·Suzanne A LigthartEdo Richard
May 14, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Hanneke JoostenRon T Gansevoort
Feb 24, 2012·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Mohammed A MohammedTom Marshall
May 1, 2012·The Clinical Neuropsychologist·Matthew CalamiaDaniel Tranel
Aug 14, 2012·Journal of Alzheimer's Disease : JAD·Florence Richard, Florence Pasquier
Jun 15, 2013·Expert Review of Pharmacoeconomics & Outcomes Research·Sipke T VisserMaarten J Postma
Jan 15, 2015·Nature Reviews. Cardiology·Chengxuan Qiu, Laura Fratiglioni
Apr 1, 2016·BMJ : British Medical Journal·Jannick A N DorresteijnPaul M Ridker
Sep 9, 2017·Stroke; a Journal of Cerebral Circulation·Philip B GorelickUNKNOWN American Heart Association/American Stroke Association
Jan 29, 2019·JAMA : the Journal of the American Medical Association·UNKNOWN SPRINT MIND Investigators for the SPRINT Research GroupClinton B Wright

❮ Previous
Next ❯

Citations

Sep 8, 2021·JAMA Internal Medicine·Nicolien A van VlietUNKNOWN Thyroid Studies Collaboration

❮ Previous
Next ❯

Software Mentioned

SPSS Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.