PMID: 9169299May 1, 1997Paper

Pharmacological treatment of severely depressed patients: a meta-analysis comparing efficacy of mirtazapine and amitriptyline

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
S KasperA G Pols

Abstract

Efficacy data were available from 405 severely depressed patients (baseline 17-item Hamilton Rating Scale for Depression-HAMD scores > or = 25) participating in randomized, double-blind, amitriptyline-controlled studies of mirtazapine. Main efficacy variable were changes from baseline in the group mean 17-item HAMD scores and responder rates. Secondary efficacy variables were changes in depressed mood item on the HAMD and in factors derived from the 17-item HAMD scale. Treatment with either mirtazapine or amitriptyline resulted in robust reductions of baseline HAMD scores and in similar and high percentages of responders. Both drugs produced favourable effects on depressed mood and on symptoms commonly associated with depression, such as anxiety, sleep and vegetative disturbances. There were neither statistically significant nor clinically relevant differences between mirtazapine and amitriptyline at any assessment point nor at endpoint. The results demonstrate that the new antidepressant mirtazapine and the tricyclic antidepressant amitriptyline are equally effective in the treatment of severely depressed patients.

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Citations

Jan 1, 1998·European Psychiatry : the Journal of the Association of European Psychiatrists·J Mendlewicz
Jan 15, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A KonstantinidisS Kasper
Oct 6, 2007·International Clinical Psychopharmacology·Richard C SheltonMichael J Detke
Jul 28, 2006·Journal of Psychiatric Research·Charles B Nemeroff
Mar 16, 2007·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·W Stephen WaringD Nicholas Bateman
Oct 31, 2002·Human Psychopharmacology·Sidney H KennedyR Michael Bagby
Jun 4, 2018·The International Journal of Neuropsychopharmacology·Markus DoldSiegfried Kasper
Dec 14, 2011·The Cochrane Database of Systematic Reviews·Norio WatanabeToshi A Furukawa

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