Pharmacologically active compounds in the Anoectochilus and Goodyera species.

Journal of Natural Medicines
Xiao-Ming DuYukihiro Shoyama

Abstract

The extract of Anoectochilus formosanus showed significant activity in decreasing the levels of the cytosolic enzymes LDH, GOT, and GPT, and the result demonstrated that A. formosanus possessed prominent hepatoprotective activity against CCl(4)-induced hepatotoxicity. Moreover, in the results of the test using aurothioglucose-induced obese mice, the extract showed a significant antihyperliposis effect. A. formosanus grown in the wild and propagated by tissue culture contain ten compounds, including a major known component, (3R)-3-(beta-D-glucopyranosyloxy)butanolide (kinsenoside; 1), and two new components, (3R)-3-(beta-D-glucopyranosyloxy)-4-hydroxybutanoic acid (2) and 2-[(beta-D-glucopyranosyloxy)methyl]-5-hydroxymethylfuran (3), along with the known compounds, isopropyl-beta-D-glucopyranoside (4), (R)-3,4-dihydroxybutanoic acid gamma-lactone (5), 4-(beta-D-glucopyranosyloxy) benzyl alcohol (6), (6R,9S)-9-(beta-D-glucopyranosyloxy)megastigma-4,7-dien-3-one (7), and (3R)-3-(beta-D-glucopyranosyloxy)-4-hydroxybutanolide (8). Since a higher concentration of kinsenoside (1) was detected in the crude drugs A. formosanus and A. koshunensis by high-performance liquid chromatography (HPLC) analysis, we proved a simple purification s...Continue Reading

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Citations

Nov 13, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H-B HsiaoW-C Lin
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Feng ZhangHaihong Huang
Jun 10, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Kur-Ta ChengShu-Hui Juan
Jun 21, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shaheed Ur RehmanHye Hyun Yoo
Oct 30, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ming XiangYonghui Zhang
Nov 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hsiao-Hang ChungJen-Tsung Chen
Aug 4, 2018·Current Medical Science·Chang-Xing QiYong-Hui Zhang
Nov 24, 2020·Bioorganic & Medicinal Chemistry·Wei SongHongxiang Lou
Jun 29, 2012·Journal of Natural Products·Asim MuhammadJohn T Arnason

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