Abstract
The extract of Anoectochilus formosanus showed significant activity in decreasing the levels of the cytosolic enzymes LDH, GOT, and GPT, and the result demonstrated that A. formosanus possessed prominent hepatoprotective activity against CCl(4)-induced hepatotoxicity. Moreover, in the results of the test using aurothioglucose-induced obese mice, the extract showed a significant antihyperliposis effect. A. formosanus grown in the wild and propagated by tissue culture contain ten compounds, including a major known component, (3R)-3-(beta-D-glucopyranosyloxy)butanolide (kinsenoside; 1), and two new components, (3R)-3-(beta-D-glucopyranosyloxy)-4-hydroxybutanoic acid (2) and 2-[(beta-D-glucopyranosyloxy)methyl]-5-hydroxymethylfuran (3), along with the known compounds, isopropyl-beta-D-glucopyranoside (4), (R)-3,4-dihydroxybutanoic acid gamma-lactone (5), 4-(beta-D-glucopyranosyloxy) benzyl alcohol (6), (6R,9S)-9-(beta-D-glucopyranosyloxy)megastigma-4,7-dien-3-one (7), and (3R)-3-(beta-D-glucopyranosyloxy)-4-hydroxybutanolide (8). Since a higher concentration of kinsenoside (1) was detected in the crude drugs A. formosanus and A. koshunensis by high-performance liquid chromatography (HPLC) analysis, we proved a simple purification s...Continue Reading
References
Nov 15, 1990·Biochemical Pharmacology·J H MedinaC Peña
Jan 1, 1989·Pathology and Immunopathology Research·G A Clawson
Jan 1, 1986·Epilepsia·B S Meldrum, A G Chapman
Jan 1, 1988·Journal of Neural Transmission·R L Macdonald
May 1, 1988·Japanese Journal of Medicine·H NomuraM Goto
Jun 1, 1986·Radiology·P R JollesW P Jones
Dec 1, 1986·Clinical Science·T S MelkiP W Ramwell
Apr 27, 1985·British Medical Journal·U GoldbourtH N Neufeld
Jan 1, 1971·Annals of Internal Medicine·W B KannelP M McNamara
Jul 1, 1966·The American Journal of Physiology·P W Han, A C Liu
Jun 1, 1995·Planta medica·H ViolaA C Paladini
Aug 1, 1994·Phytochemistry·A ItoK Yamasaki
Jan 1, 1994·Pharmacology, Biochemistry, and Behavior·C WolfmanJ H Medina
Jan 1, 1993·Critical Reviews in Toxicology·J L RaucyJ M Lasker
Apr 1, 1993·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Y NiihoT Kurashige
Mar 1, 1997·Chemical & Pharmaceutical Bulletin·M YoshikawaH Matsuda
Jul 17, 1998·Phytochemistry·X M DuK Miyahara
Jul 20, 1999·The Journal of Pharmacy and Pharmacology·A C PaladiniJ H Medina
May 23, 2000·Phytochemistry·X M DuY Shoyama
Jun 23, 2000·Biological & Pharmaceutical Bulletin·X M DuY Shoyama
Feb 24, 2001·Biological & Pharmaceutical Bulletin·X DuY Shoyama
Mar 1, 1965·The Journal of Experimental Medicine·G BRECHERI L SCHWARTZ
Jan 30, 2007·Planta medica·W Y GaoD Y Zhu
Mar 1, 1949·Proceedings of the Society for Experimental Biology and Medicine·G BRECHER, S H WAXLER
Oct 1, 1946·Physiological Reviews·J R BROBECK
Citations
Nov 13, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H-B HsiaoW-C Lin
Apr 7, 2010·Journal of Medicinal Chemistry·Sunetra RayJon C Mirsalis
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Feng ZhangHaihong Huang
Mar 2, 2010·Biological & Pharmaceutical Bulletin·Fusheng ZhangShunxing Guo
Apr 10, 2010·Bioscience, Biotechnology, and Biochemistry·Jin-Bin WuWen-Chuan Lin
Feb 12, 2014·PloS One·Qingsong ShaoMingyan Li
Dec 22, 2015·Journal of Pharmaceutical and Biomedical Analysis·Shaheed Ur RehmanHye Hyun Yoo
Jun 25, 2015·Planta·Tongwei LvLili Zhang
Jun 10, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Kur-Ta ChengShu-Hui Juan
Mar 19, 2013·Fitoterapia·Zhen-Ling LiuYa Li
Apr 8, 2011·Journal of Ethnopharmacology·Wen-Tsong HsiehWen-Chuan Lin
Apr 5, 2014·Natural Product Research·Qing LiuYin-Qian Liu
Jun 21, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shaheed Ur RehmanHye Hyun Yoo
Oct 30, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ming XiangYonghui Zhang
Nov 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hsiao-Hang ChungJen-Tsung Chen
Dec 28, 2011·Molecular Biology Reports·Gang ZhangShunxing Guo
Jul 28, 2010·Shock·Hung-Bo HsiaoWen-Chuan Lin
Mar 28, 2020·Phytochemical Analysis : PCA·Mi WeiLongjiang Yu
Aug 4, 2018·Current Medical Science·Chang-Xing QiYong-Hui Zhang
Sep 9, 2017·Frontiers in Plant Science·Mengjie XuYanjing Li
Jul 11, 2018·Pharmaceutics·Xin ZhangJiangeng Huang
Nov 24, 2020·Bioorganic & Medicinal Chemistry·Wei SongHongxiang Lou
Jun 29, 2012·Journal of Natural Products·Asim MuhammadJohn T Arnason