PMID: 708487Aug 1, 1978Paper

Pharmacologically induced hypolipidemia. The ethinyl estradiol-treated rat

R A Davis, P S Roheim


The aim of this study was to examine in detail the lipid and apoprotein concentrations in the serum of rats treated with pharmacologic doses (5 mg/kg/d for 5 d) of the synthetic estrogen derivative ethinyl estradiol. The results show that in rats, estrogen-induced hypolipidemia is associated with a nearly complete absence of the lipid and protein moieties normally found in d less than 1.21 fraction of serum. Quantitation of specific apolipoproteins by immunoelectrophoresis show that most apolipoproteins are decreased by more than 90% in the serum of estrogen-treated rats. In contrast to the changes in d less than 1.21 lipoproteins, estrogen treatment only slightly reduced serum phospholipid concentrations (by only 10%) and caused no change in the concentration of serum albumin. The results show that the ethinyl estradiol-treated rat is an excellent model of drug-induced hypolipidemia.


May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·P S RoheimG G Pinter
May 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·I WeinsteinM Veldhuis
Oct 1, 1975·The Journal of Clinical Investigation·H J Kim, R K Kalkhoff
Feb 1, 1967·Endocrinology·M E FewsterD A Turner
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON


Feb 12, 1986·Biochimica Et Biophysica Acta·R C MaranhaoT G Redgrave
Feb 9, 1995·Biochimica Et Biophysica Acta·D Fu, C A Hornick
Jan 1, 1989·Pharmacology & Therapeutics·R A DavisL H Junker
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·F LabrieR Veilleux
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J G DeLamatreP S Roheim
May 16, 1983·Biochimica Et Biophysica Acta·B C McNamara, G S Boyd
Jul 24, 1981·Biochimica Et Biophysica Acta·R A DavisP S Roheim
Jun 1, 1988·American Journal of Obstetrics and Gynecology·R H Knopp
Mar 1, 1987·Scandinavian Journal of Gastroenterology·B Landin, A Nilsson
Jan 1, 1980·Annals of the New York Academy of Sciences·M S BrownJ L Goldstein
May 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C J Steer, R D Klausner
Mar 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A D AttieD Steinberg
Jan 11, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R S KushwahaH C McGill
Dec 16, 1997·Biochimica Et Biophysica Acta·J W Burgess, K K Stanley

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