Pharmacology and clinical use of voriconazole

Expert Opinion on Drug Metabolism & Toxicology
George R Thompson, James S Lewis

Abstract

Voriconazole is an extended-spectrum triazole developed specifically to target Aspergillus spp. and is now indicated as primary therapy in this circumstance. However, it has a broad spectrum of activity against both yeasts and molds and is also a viable treatment option in the treatment of other mycoses. This review discusses the mechanism of action, the pharmacodynamics and pharmacokinetics and the most common mechanisms of resistance to this agent. An overview of therapeutic drug monitoring, drug-drug interactions and pivotal trials are also reviewed. The reader will gain further knowledge of the unique aspects of voriconazole compared to other currently available antifungal agents. Voriconazole offers distinct advantages over several other antifungals. The side effect profile of voriconazole is unique compared to other triazole agents. Concern for drug-drug interactions due to a frequently shared common metabolic pathway has prompted heightened interest in the use of therapeutic drug monitoring for concerns of toxicity, drug-drug interactions and in attempts to ensure efficacy. These aspects as well as a review of important clinical information pertaining to voriconazole are discussed here.

References

Feb 1, 1985·Current Eye Research·D M O'DayJ M Freeman
May 1, 1994·Clinical Pharmacology and Therapeutics·K T OlkkolaP J Neuvonen
Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J N GalgianiP L Williams
Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S W ChapmanC A Kauffman
Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C A KauffmanS W Chapman
Aug 30, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A H Groll, T J Walsh
Sep 15, 2001·Medical Mycology·M R McGinnisD W Warnock
Sep 29, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R AllyUNKNOWN Esophageal Candidiasis Study Group
Jan 25, 2002·The New England Journal of Medicine·Thomas J WalshUNKNOWN National Institute of Allergy and Infectious Diseases Mycoses Study Group
Jan 25, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David W DenningHartmut Lode
Apr 9, 2002·Journal of Clinical Pharmacology·Hillard M LazarusAlain Romero
Apr 17, 2002·Clinical Pharmacology and Therapeutics·Alain J RomeroNolan Wood
May 15, 2002·The Pediatric Infectious Disease Journal·Thomas J WalshJohn R Perfect
Jul 18, 2002·Antimicrobial Agents and Chemotherapy·L PurkinsD Kleinermans
Aug 9, 2002·The New England Journal of Medicine·Raoul HerbrechtUNKNOWN Invasive Fungal Infections Group of the European Organisation for Research and Treatment of Cancer and the Global Aspergillu
Jan 15, 2003·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S FournierJ M Molina
Feb 21, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Leonard B Johnson, Carol A Kauffman
Mar 26, 2003·Antimicrobial Agents and Chemotherapy·Takashi FukuokaScott G Filler
Apr 10, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Manjunath P Pai, Sarah Allen
Apr 26, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John R PerfectElizabeth Johnson
May 20, 2003·Infectious Disease Clinics of North America·Andreas H GrollThomas J Walsh
Jun 25, 2003·Antimicrobial Agents and Chemotherapy·Margarita GarauAmalia del Palacio
Aug 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Irja LutsarPeter Troke
Sep 5, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Henriette J ScherpbierTaco W Kuijpers
Nov 18, 2003·British Journal of Clinical Pharmacology·Lynn PurkinsDon Nichols
Nov 18, 2003·British Journal of Clinical Pharmacology·Lynn PurkinsDon Nichols
Nov 18, 2003·British Journal of Clinical Pharmacology·Lynn PurkinsAnitra Fielding
Jan 14, 2004·Archives of Ophthalmology·Seenu M HariprasadRandall A Prince
Jan 30, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E Bouza, P Muñoz
May 6, 2004·American Journal of Ophthalmology·Fabiana Bogossion MarangonEduardo C Alfonso
May 25, 2004·Antimicrobial Agents and Chemotherapy·Thomas J WalshNolan Wood
Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kieren A MarrLawrence Corey
Jan 7, 2005·Journal of Clinical Microbiology·D J DiekemaM A Pfaller
Mar 26, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Houria MouasUNKNOWN Voriconazole/Bone Invasive Aspergillosis Study Group
May 26, 2005·The Annals of Pharmacotherapy·Lana GerzenshteinJohn P Flaherty

❮ Previous
Next ❯

Citations

Apr 11, 2013·Antimicrobial Agents and Chemotherapy·Johan G C van HasseltAntoinette Y N Schouten-van Meeteren
Oct 12, 2010·Clinical Microbiology Reviews·Sanjay G Revankar, Deanna A Sutton
Jul 18, 2012·Polish journal of radiology·Anna Janik-MoszantTomasz Szczepański
Oct 4, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Thomas CherianAnita Verma
Mar 22, 2014·Case Reports in Otolaryngology·Jenny Walton, Chris Coulson
Feb 22, 2016·Infectious Disease Clinics of North America·Jose CadenaThomas F Patterson
Apr 7, 2015·Expert Review of Anti-infective Therapy·David AllenJohn Perfect
Aug 13, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Si-Hyun KimJin-Hong Yoo
Sep 1, 2016·The Journal of Antibiotics·Ikuko NakamuraKazuhisa Sekimizu
Nov 12, 2016·Survey of Ophthalmology·Linda Christian Carrijo-CarvalhoFabio Ramos de Souza Carvalho
Feb 15, 2018·Antimicrobial Agents and Chemotherapy·Thomas ColleyGarth Rapeport
Nov 21, 2018·Antimicrobial Agents and Chemotherapy·George R ThompsonStephen D White
Sep 23, 2014·Expert Review of Anti-infective Therapy·Matthew L EldridgeGeorge R Thompson
Oct 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Emil SzepińskiSławomir Milewski
Jan 9, 2013·Therapeutic Drug Monitoring·Isabel SprietLudo Willems
Mar 4, 2011·Medical Mycology·Melanie W PoundRichard H Drew
Dec 26, 2018·Journal of Chemotherapy·Sara Blanco-DoradoMaría J Lamas
Dec 20, 2020·Pharmacology Research & Perspectives·Lindsey CassGarth Rapeport
May 22, 2021·Infectious Disease Clinics of North America·Jose CadenaThomas F Patterson
May 21, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Kazuhiro ItoPete Strong
Aug 6, 2021·Journal of Basic Microbiology·Saraswathi NagarajShoba Narayan
Nov 28, 2021·Journal of Fungi·Abid A HaseebAhmed B Sallam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Henriette J ScherpbierTaco W Kuijpers
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
K A MarrLawrence Corey
© 2022 Meta ULC. All rights reserved