Pharmacology and pharmacokinetics of flutamide.

Urology
R Neri

Abstract

Flutamide is rapidly metabolized by hydroxylation of the side chain to SCH 16423 (alpha, alpha, alpha-trifluoro-2-methyl-4'-nitro-m-lactotoluidide), the major metabolic product in all species studied, which is biologically active in vivo and in vitro studies. Flutamide exhibits its antiandrogenic activity by inhibiting androgen uptake and/or inhibition of nuclear binding of the androgens in the target tissues. At daily doses from 1 to 50 mg/kg body weight, flutamide reduced seminal vesicle and ventral prostate weights of intact male rats without affecting sexual potency. In addition, flutamide reduced the rate of DNA synthesis in the prostate of rats to a greater degree than other steroidal antiandrogens. The antiandrogenic activity was corroborated by the inhibition of androgen-induced prostate hypertrophy in orchiectomized rats through the use of testosterone, testosterone propionate, dihydrotestosterone, androstenedione, and dehydroepiandrosterone. Flutamide, given orally, reduced prostatic size in aged dogs with benign prostate hyperplasia after six weeks and one year. The baboon prostate was also reduced in size when flutamide was administered three times a week for four weeks.

References

Jul 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·J MüntzingA A Sandberg

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Citations

Jun 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Goulding, E Gold
Jan 1, 1991·Cancer Chemotherapy and Pharmacology·R H AsadeJ Tessler
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·G BoccuzziO Danni
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·M Di MonacoG Boccuzzi
Aug 6, 2002·European Journal of Medicinal Chemistry·Yali HeDuane D Miller
Jan 12, 1995·The New England Journal of Medicine·J E Oesterling
Jul 22, 2006·American Journal of Therapeutics·Steven R AlbertsCharles L Loprinzi
Jan 22, 2004·Science's STKE : Signal Transduction Knowledge Environment·Yehia Daaka
Nov 12, 2013·Hormones and Behavior·Panida LoutchanwootHubertus Jarry
Apr 5, 2011·International Journal of Pharmaceutics·Nazik ElgindyAhmed Elzoghby
May 26, 2006·Molecular and Cellular Endocrinology·Mirjami M MattilaPirkko L Härkönen
Apr 11, 2014·General and Comparative Endocrinology·P L Rangel, C G Gutierrez
Mar 26, 1998·Biochemical and Biophysical Research Communications·J T DaltonD D Miller
May 8, 2018·The Journal of Urology·E David CrawfordFernand Labrie
Jul 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·B Bissonnette, P J Sullivan
Mar 9, 2019·British Journal of Pharmacology·Victoria M McLeodBradley J Turner
Mar 17, 2007·Journal of Receptor and Signal Transduction Research·Laura K Potter, Frank L Tobin
Mar 12, 1999·British Journal of Clinical Pharmacology·S AnjumC E Halstenson
Jun 30, 2004·Journal of Andrology·Jeremiah C MurphyMartha K Terris
Mar 1, 1996·The American Journal of Physiology·A C GallagherJ H Tobias
Sep 21, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Namita MahadikRajkumar Banerjee

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