Pharmacology and structure-activity relationships of bioactive polycyclic cage compounds: a focus on pentacycloundecane derivatives

Medicinal Research Reviews
Werner J GeldenhuysCornelis J Van der Schyf

Abstract

The chemistry of organic polycyclic cage compounds has intrigued medicinal chemists for over 50 years, yet little is published about their pharmacological profiles. Polycyclic cage compounds have important pharmaceutical applications, ranging from the symptomatic and proposed curative treatment of neurodegenerative diseases such as Parkinson's and Alzheimer's disease (e.g., amantadine and memantine), to use as anti-viral agents against influenza and the immunodeficiency virus (HIV). The polycyclic cage appears to be a useful scaffold to yield drugs with a wide scope of applications, and can be used also to modify and improve the pharmacokinetic and pharmacodynamic properties of drugs in current use. This review attempts to summarize the pharmacological profiles of polycyclic cage compounds with an emphasis on the lesser known pentacycloundecanes, homocubanes, and trishomocubanes.

References

Jul 1, 1976·Journal of Medicinal Chemistry·J K ChakrabartiD E Tupper
Feb 1, 1991·Journal of Medicinal Chemistry·D W OliverT G Fourie
Jan 1, 1985·Biotechnology & Genetic Engineering Reviews·H Umezawa
May 1, 1986·Archiv der Pharmazie·C J van der SchyfF O Snyckers
May 1, 1986·Pharmacological Research Communications·C J Van der SchyfW A Coetzee
Jun 1, 1972·Harefuah·M Streifler, U Kallay
Sep 1, 1965·Journal of Medicinal Chemistry·R T RapalaK Gerzon
Jan 1, 1981·Progress in Medicinal Chemistry·J W Tilley, M J Kramer
Jul 1, 1997·Neuroscience and Biobehavioral Reviews·W DanyszG Quack
Aug 6, 1997·European Journal of Pharmacology·M J O'NeillD Bleakman
Dec 16, 1998·European Journal of Pharmacology·V H NguyenM J Christie
Feb 20, 1999·The Journal of Biological Chemistry·C S GandhiL H Pinto
Apr 1, 1999·Nuclear Medicine and Biology·V H NguyenM D Christie
Nov 4, 2000·Expert Opinion on Investigational Drugs·K K Jain
Apr 13, 2001·Drug Discovery Today·W M. Pardridge
May 23, 2001·Chemical Research in Toxicology·K P CastagnoliN Castagnoli
Mar 21, 2002·Fundamental & Clinical Pharmacology·Laurent Monassier, Pascal Bousquet
May 31, 2002·Journal of Medicinal Chemistry·Daniel F VeberKenneth D Kopple
Aug 30, 2002·Neurotoxicology and Teratology·Samuel G Speciale
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Terrence M TumpeyChristopher F Basler
Oct 31, 2002·Nature Neuroscience·John A Kemp, Ruth M McKernan
Dec 4, 2002·Nature Reviews. Neuroscience·Julie Lotharius, Patrik Brundin

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Citations

May 6, 2009·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Eric BrantleyKavita Babu
Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Cornelis J Van der Schyf, Werner J Geldenhuys
Mar 25, 2011·Future Medicinal Chemistry·Igor A LevandovskiyTatyana E Shubina
Feb 12, 2015·The Journal of Chemical Physics·Reinhard MeinkeJanina Maultzsch
Oct 24, 2014·The European Physical Journal. E, Soft Matter·Frank C MaierMaria Fyta
Dec 13, 2012·Expert Opinion on Drug Discovery·Werner J Geldenhuys, Cornelis J Van der Schyf
Feb 4, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raju Suresh KumarHasnah Osman
Oct 24, 2006·Journal of Neurochemistry·Cornelis J Van der SchyfMoussa B H Youdim
Jan 19, 2011·Chemical Biology & Drug Design·Oluseye K OnajolePatrick Govender
Dec 3, 2014·Journal of Peptide Science : an Official Publication of the European Peptide Society·Maxime Grillaud, Alberto Bianco
Aug 8, 2012·European Journal of Medicinal Chemistry·Maya M MakatiniHendrik G Kruger
Feb 1, 2008·Brain Research·Jiukuan HaoUlrich Bickel
Sep 12, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Felicia Megumi ItoCláudia do O Pessoa
May 6, 2016·Biopharmaceutics & Drug Disposition·Toyofumi SuzukiKazuo Tomono
Aug 26, 2014·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Frank C Maier, Maria Fyta
Feb 1, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rajan SharmaSarel F Malan
Jan 16, 2015·Physical Chemistry Chemical Physics : PCCP·Robert RichterAndrea Merli
Feb 7, 2012·ChemMedChem·Jacques JoubertSarel F Malan
Jan 22, 2008·Chemical Biology & Drug Design·Fernando AlbericioSamran Prabpai
Sep 23, 2008·Magnetic Resonance in Chemistry : MRC·Oluseye K OnajoleHendrik G Kruger
Jun 14, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·Krishna BisettyJuan J Perez
Jan 20, 2010·Magnetic Resonance in Chemistry : MRC·Oluseye K OnajoleHendrik G Kruger
May 18, 2010·Magnetic Resonance in Chemistry : MRC·Mohamed S AltaibHendrik G Kruger
Dec 14, 2005·Biopolymers·Krishna BisettyHendrik G Kruger
Mar 7, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Sebusi OdisitseAmith Singh
Jan 31, 2020·Organic & Biomolecular Chemistry·Sambasivarao Kotha, Subba Rao Cheekatla
Feb 11, 2020·Current Pharmaceutical Design·Vasiliki PardaliGrigoris Zoidis
Mar 22, 2016·Marine Drugs·Sofia-Eléna MotuhiStéphane Bach
May 31, 2006·Neurochemical Research·Cornelia KiewertJochen Klein
Mar 13, 2014·Nanoscale·Ganesh Sivaraman, Maria Fyta
Dec 18, 2019·Organic & Biomolecular Chemistry·Ilya M TkachenkoYuri N Klimochkin
Aug 31, 2012·Chemical Communications : Chem Comm·Ronald GriggHussien H Abbas-Temirek
Nov 15, 2011·Journal of Peptide Science : an Official Publication of the European Peptide Society·Maya MakatiniHendrik G Kruger
Mar 6, 2021·Journal of Molecular Graphics & Modelling·A M S SantosD L Azevedo
Mar 25, 2009·The Journal of Physical Chemistry. B·Krishna Bisetty, Juan J Perez

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