PMID: 6976847Jan 1, 1981Paper

Pharmacology of 8-aminoquinolines

Bulletin of the World Health Organization
R S Grewal

Abstract

The 8-aminoquinolines were the first group of compounds to be synthesized specifically for their antimalarial activity. A large-scale research programme in the United States of America in the 1940s produced three new antimalarial drugs-pentaquine, isopentaquine, and primaquine -of which primaquine was the most effective. This article reviews knowledge on the activity of these 8-aminoquinolines against all stages of the malaria parasite and suggests their possible modes of action. The toxic effects and possible causal mechanisms are also outlined.

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