Pharmacology of anticoagulants used in the treatment of venous thromboembolism

Journal of Thrombosis and Thrombolysis
Edith NutescuAnn K Wittkowsky

Abstract

Anticoagulant drugs are the foundation of therapy for patients with VTE. While effective therapeutic agents, anticoagulants can also result in hemorrhage and other side effects. Thus, anticoagulant therapy selection should be guided by the risks, benefits and pharmacologic characteristics of each agent for each patient. Safe use of anticoagulants requires not only an in-depth knowledge of their pharmacologic properties but also a comprehensive approach to patient management and education. This paper will summarize the key pharmacologic properties of the anticoagulant agents used in the treatment of patients with VTE.

References

May 30, 1991·The New England Journal of Medicine·J Hirsh
Apr 1, 1974·Clinical Pharmacology and Therapeutics·A BreckenridgeR Gibbons
Jul 1, 1980·Clinical Pharmacology and Therapeutics·C HigniteD Azarnoff
Sep 12, 1980·JAMA : the Journal of the American Medical Association·A M Walker, H Jick
Jun 1, 1994·British Journal of Clinical Pharmacology·E ChanM Rowland
Feb 1, 1994·American Journal of Clinical Pathology·J Hammer
Feb 14, 1994·Archives of Internal Medicine·J Hirsh, L Poller
Jul 1, 1995·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Y Stirling
Apr 22, 1996·Archives of Internal Medicine·N R CampbellG E Raskob
Sep 4, 1997·The New England Journal of Medicine·J I Weitz
Sep 30, 2000·Seminars in Thrombosis and Hemostasis·M M Samama, G T Gerotziafas
Apr 26, 2001·The New England Journal of Medicine·T E Warkentin, J G Kelton
Oct 18, 2002·Clinical Pharmacokinetics·François DonatRik de Greef
Sep 10, 2003·Clinical Pharmacokinetics·Jawed FareedTaqdees Sheikh
Jun 17, 2004·Seminars in Vascular Medicine·Ann K Daly, Guruprasad P Aithal
Jun 30, 2004·Pharmacotherapy·Terry K Rosborough, Michele F Shepherd
Sep 1, 2004·Pharmacotherapy·Henry BusseyUNKNOWN Heparin Consensus Group
Jan 11, 2005·Hematology/oncology Clinics of North America·Rodger L BickDeborah A Hoppensteadt
Apr 12, 2005·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·James M WilsonKathleen Pinto
Apr 28, 2005·The Annals of Pharmacotherapy·Sarah A SpinlerAnn K Wittkowsky
Dec 19, 2006·Transfusion Medicine Reviews·Sam Schulman, Nick R Bijsterveld
Mar 6, 2007·Critical Care Medicine·Kathleen SellengAndreas Greinacher
Oct 4, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Nirmala RaghavanDonglu Zhang
Nov 26, 2008·European Journal of Clinical Pharmacology·Jonatan D LindhAnders Rane
Aug 22, 2009·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Joachim Stangier, Andreas Clemens
Nov 3, 2009·Journal of Thrombosis and Thrombolysis·Daniel S Weitz, Jeffrey I Weitz
Jan 15, 2010·Clinical Pharmacology and Therapeutics·L H CavallariJ A Johnson
Feb 20, 2010·Current Topics in Medicinal Chemistry·Alexander StraubAlexander Hillisch
Jul 16, 2010·Journal of Thrombosis and Haemostasis : JTH·K HasanD G Hackam
Nov 9, 2010·Nature Biotechnology·Emma Dorey
Feb 4, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Meyer M Samama, Céline Guinet
Jul 7, 2011·Journal of Thrombosis and Haemostasis : JTH·M LeviP W Kamphuisen

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Citations

Jun 11, 2016·Current Opinion in Allergy and Clinical Immunology·Purificación Gonzalez-Delgado, Javier Fernandez
Jun 29, 2017·British Journal of Biomedical Science·C J Donaldson, D J Harrington
Jul 6, 2017·Hämostaseologie·Robert C GosselinDorothy Adcock
Oct 5, 2017·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Bruna Bergmann SantosGiovanna Webster Negretto
Dec 5, 2018·Expert Opinion on Pharmacotherapy·Marc LaineLaurent Bonello
Apr 5, 2019·Journal of Thrombosis and Thrombolysis·Nameer van OosteromMichael Barras
May 11, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Samuel DubinskyUrban Emmenegger
Nov 11, 2017·Journal of Oncology Practice·Joseph J ShatzelThomas G DeLoughery
Jun 4, 2019·Critical Care Nurse·Melissa A Nestor, Bryan Boling
Nov 26, 2019·Clinical Practice and Cases in Emergency Medicine·C James WatsonMichael Ganetsky
Mar 7, 2020·Nature Reviews. Drug Discovery·Nigel MackmanJeffrey I Weitz
Apr 30, 2020·Journal of Thrombosis and Thrombolysis·David RodriguezFrancisco Nevarez
Aug 7, 2019·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Emily Gottenborg, Gregory J Misky
Aug 18, 2020·International Journal of General Medicine·Hisham A BadreldinMohamed Salih Aziz Mohamed
Feb 25, 2021·British Journal of Clinical Pharmacology·Jerome Roy SemakulaCatriona Waitt
Apr 20, 2021·Journal of Vascular Surgery. Venous and Lymphatic Disorders·Daniel D MyersThomas Wakefield
May 8, 2021·Journal of Pharmacy Practice·Dovena LazaridisNathaniel Eraikhuemen
Jun 18, 2021·The Annals of Pharmacotherapy·Maureen A SmytheCandice L Garwood
Aug 8, 2021·Journal of Clinical Medicine·Phillip C NguyenJames D McFadyen

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