Pharmacology of antithrombotic drugs: an assessment of oral antiplatelet and anticoagulant treatments

Lancet
Jessica L Mega, Tabassome Simon

Abstract

Antithrombotic drugs, which include antiplatelet and anticoagulant therapies, prevent and treat many cardiovascular disorders and, as such, are some of the most commonly prescribed drugs worldwide. The first drugs designed to inhibit platelets or coagulation factors, such as the antiplatelet clopidogrel and the anticoagulant warfarin, significantly reduced the risk of thrombotic events at the cost of increased bleeding in patients. However, both clopidogrel and warfarin have some pharmacological limitations including interpatient variability in antithrombotic effects in part due to the metabolism, interactions (eg, drug, environment, and genetic), or targets of the drugs. Increased knowledge of the pharmacology of antithrombotic drugs and the mechanisms underlying thrombosis has led to the development of newer drugs with faster onset of action, fewer interactions, and less interpatient variability in their antithrombotic effects than previous antithrombotic drugs. Treatment options now include the next-generation antiplatelet drugs prasugrel and ticagrelor, and, in terms of anticoagulants, inhibitors that directly target factor IIa (dabigatran) or Xa (rivaroxaban, apixaban, edoxaban) are available. In this Series paper we revie...Continue Reading

References

Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson
Jun 23, 1971·Nature: New Biology·J B Smith, A L Willis
Jun 1, 1994·Catheterization and Cardiovascular Diagnosis·P BarraganM Bremondy
Dec 1, 1995·Journal of Clinical Pharmacology·I H BenedekD M Kornhauser
Aug 25, 2001·The New England Journal of Medicine·S YusufUNKNOWN Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators
Jan 1, 1959·Circulation·K P LINK
Sep 18, 1964·Science·E W DAVIE, O D RATNOFF
Dec 2, 2005·The New England Journal of Medicine·Carlo PatronoColin Baigent
Jan 18, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jessica L Fayer RehmelBarbara J Ring
Oct 19, 2006·JAMA : the Journal of the American Medical Association·Daniel S BudnitzJoseph L Annest
Jan 24, 2007·Journal of Thrombosis and Haemostasis : JTH·G VilahurJ J Badimon
Mar 3, 2007·Nature Clinical Practice. Cardiovascular Medicine·Andrew O MareeDesmond J Fitzgerald
Nov 6, 2007·The New England Journal of Medicine·Stephen D WiviottUNKNOWN TRITON-TIMI 38 Investigators
Nov 17, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Stefan BlechWilly Roth
Aug 30, 2008·The New England Journal of Medicine·Bruce Furie, Barbara C Furie
Dec 25, 2008·The New England Journal of Medicine·Tabassome SimonUNKNOWN French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) Investigators
Sep 1, 2009·The New England Journal of Medicine·Lars WallentinMona Thorsén
Dec 2, 2009·European Heart Journal·Dominick J AngiolilloShinya Goto
Jan 1, 2010·The New England Journal of Medicine·Donald Stuart Houston, Ryan Zarychanski
Oct 12, 2010·The New England Journal of Medicine·Deepak L BhattUNKNOWN COGENT Investigators
Mar 17, 2011·JAMA : the Journal of the American Medical Association·Matthew J PriceUNKNOWN GRAVITAS Investigators
Jul 26, 2011·The New England Journal of Medicine·John H AlexanderUNKNOWN APPRAISE-2 Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Jan 18, 2012·Circulation·George V Moukarbel, Deepak L Bhatt
Jan 21, 2012·Circulation·Shaun G GoodmanUNKNOWN Platelet Inhibition and Patient Outcomes Trial Investigators
Mar 27, 2012·The New England Journal of Medicine·David A MorrowUNKNOWN TRA 2P–TIMI 50 Steering Committee and Investigators

❮ Previous
Next ❯

Citations

Jan 23, 2016·Integrative Biology : Quantitative Biosciences From Nano to Macro·Leo BoneschanskerDaniel Irimia
Feb 14, 2016·Life Sciences·Eduardo Fuentes, Iván Palomo
Nov 19, 2015·Journal of Ethnopharmacology·Xueqing XuShuwen Liu
Aug 19, 2015·Progress in Cardiovascular Diseases·Francesco FranchiDominick J Angiolillo
Sep 18, 2015·Experimental Hematology & Oncology·Arundhati Das, Delong Liu
Apr 2, 2016·Archives of Biochemistry and Biophysics·Kenji MiyamotoYuzuru Ikehara
Mar 18, 2015·Lancet·Stephen D Wiviott, Philippe Gabriel Steg
Jun 19, 2015·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Joon Sung Kim, Byung-Wook Kim
May 7, 2016·The Nurse Practitioner·Patricia A SchweickertMary E Jensen
May 22, 2016·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Eugenio StabileBruno Trimarco
Jun 21, 2016·European Journal of Medicinal Chemistry·Nirav R PatelMange Ram Yadav
May 29, 2016·The Medical Clinics of North America·Joana Lima Ferreira, Joyce E Wipf
Oct 25, 2016·The American Journal of Medicine·Megan E BarraSamuel Z Goldhaber
Aug 5, 2016·International Journal of Clinical Pharmacy·Shujuan ZhaoJingjing Cao
Oct 8, 2016·Internal and Emergency Medicine·Ajay YadlapatiJames D Flaherty
Sep 30, 2016·Expert Opinion on Pharmacotherapy·Benilde Cosmi
Jan 31, 2017·Basic & Clinical Pharmacology & Toxicology·Maja HellfritzschAnton Pottegård
Jun 8, 2017·Journal of Cardiovascular Pharmacology and Therapeutics·Bridget Paravattil, Hazem Elewa
Jun 9, 2017·British Journal of Clinical Pharmacology·Jenneke LeentjensCornelis Kramers
Sep 8, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Jing SunYu-Ming Li
Apr 4, 2017·Biomolecules & Therapeutics·Joo Hee KimHye Sun Gwak
Jul 17, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Amira MiraKuniyoshi Shimizu
Jun 24, 2017·Journal of Cutaneous Medicine and Surgery·Trang T Vu, Melinda Gooderham
Jul 3, 2018·The Cochrane Database of Systematic Reviews·Eveline T EngelenKarin Pm van Galen
Jun 27, 2018·European Heart Journal. Cardiovascular Pharmacotherapy·Caroline Sindet-PedersenJonas Bjerring Olesen
Dec 29, 2016·Circulation·Tabassome Simon, Nicolas Danchin
Feb 20, 2016·Circulation Research·Nina P PaynterDaniel I Chasman
Oct 17, 2018·Basic & Clinical Pharmacology & Toxicology·Per DamkierAnton Pottegård
May 21, 2019·Chemical Biology & Drug Design·Huimin LiHaitao Zhang
Jul 19, 2019·Clinical Cardiology·Kaja AblefoniAndreas Bollmann
Jun 9, 2017·Clinical Science·Erik WesteinAnna C Calkin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Trends in Cardiovascular Medicine
Mikhail S Dzeshka, Gregory Y H Lip
Current Neurology and Neuroscience Reports
Michael Levine, Joshua N Goldstein
Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
Jean-Pierre Bassand
Nihon rinsho. Japanese journal of clinical medicine
Shinya Goto
© 2021 Meta ULC. All rights reserved