Pharmacology of caffeinol in embolized rabbits: clinical rating scores and intracerebral hemorrhage incidence

Experimental Neurology
Paul A LapchakJ A Zivin

Abstract

Caffeinol is currently being tested in acute ischemic stroke patients. However, little is known about the pharmacology or safety of caffeinol in preclinical embolic stroke models. We determined the pharmacological effects of caffeinol administration on clinical rating scores in rabbits following small clot embolic strokes (RSCEM). Male New Zealand white rabbits were embolized by injecting blood clots into the cerebral circulation via a carotid catheter. Behavioral analysis was conducted 24 h following embolization, allowing for the determination of the effective stroke dose (P50) or clot amount (mg) that produces neurological deficits in 50% of the rabbits. In the current study, the P50 values for the control groups were 1.32 +/- 0.23 and 1.66 +/- 0.29 mg for the bolus-injected and infused groups, respectively. Rabbits treated with caffeinol (bolus) starting 15 min following embolization had a P50 value of 1.70 +/- 1.18 mg. Caffeinol-infused rabbits had a P50 value of 2.05 +/- 0.47 and 1.67 +/- 0.48 mg for low- and high-dose ethanol, respectively. In tPA-treated rabbits (0.9 mg/kg), the group P50 was 1.58 +/- 0.43 mg. In caffeinol (bolus) and tPA-treated rabbits, we measured a decrease in the P50 value to 0.70 +/- 0.30 mg and a...Continue Reading

References

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Sep 7, 2002·Stroke; a Journal of Cerebral Circulation·Paul A LapchakJustin A Zivin
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Apr 12, 2003·Stroke; a Journal of Cerebral Circulation·Paisith PiriyawatJames C Grotta

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Citations

Apr 18, 2008·Current Cardiology Reports·Marcus R ChaconJustin A Zivin
Feb 25, 2015·Experimental Neurology·Paul A LapchakPaul D Boitano
Mar 3, 2009·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Sheryl Martin-SchildJames C Grotta
Mar 2, 2005·Pharmacology & Therapeutics·Kui XuMichael Schwarzschild
Jul 13, 2004·Experimental Neurology·L HoyteA M Buchan
Dec 17, 2008·Stroke; a Journal of Cerebral Circulation·Maria PhilipSean I Savitz

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