Pharmacology of descending noradrenergic systems in relation to motor function

Pharmacology & Therapeutics
H Ono, H Fukuda

Abstract

The function of descending noradrenergic systems in the spinal ventral horn has not been fully elucidated. We have reviewed our own findings and those of others relating to motor function of these noradrenergic systems. We studied the effects of adrenergic drugs on spinal reflexes, decerebrate rigidity, and noradrenaline release from the spinal cord in rats, and motoneuron activity in spinal cord slices isolated from adult rats. It was shown that the descending noradrenergic systems were facilitatory to the motor system, and that alpha 1-antagonistic action at the spinal cord and alpha 2-agonistic action at the brainstem inhibited spinal motor activity by blocking spinal alpha 1-receptors and by reducing the release of noradrenaline in the spinal cord, respectively.

References

May 1, 1988·Neuropharmacology·S K LongP Bevan
Aug 29, 1986·Neuroscience Letters·C J WohlbergJ C Hackman
Feb 1, 1986·Pflügers Archiv : European journal of physiology·M YoshimuraS Nishi
Sep 1, 1971·Acta Physiologica Scandinavica·I Engberg, K C Marshall
Dec 20, 1974·Nature·M Otsuka, S Konishi
Oct 1, 1974·Japanese Journal of Pharmacology·H FukudaY Kudo
Jul 1, 1966·Acta Physiologica Scandinavica·N E AndénL Vyklický
Apr 1, 1982·Neuropharmacology·D J JonesS J Enna
Apr 1, 1984·The Journal of Physiology·R A North, M Yoshimura
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·W S Young, M J Kuhar
Jul 20, 1981·Brain Research·S J Fung, C D Barnes
Feb 1, 1982·Neuropharmacology·D J JonesS J Enna
Mar 14, 1983·Brain Research·K N WestlundJ D Coulter
Feb 1, 1980·Neuropharmacology·J C StrahlendorfC D Barnes
Jul 1, 1966·The Journal of Physiology·I Engberg, R W Ryall
Feb 17, 1898·The Journal of Physiology·C S Sherrington
Jun 1, 1970·Journal of Motor Behavior·R W Christina

❮ Previous
Next ❯

Citations

Sep 26, 1996·European Journal of Pharmacology·T WadaH Ono
Jun 16, 2004·Behavioural Brain Research·Kenichi MishimaMichihiro Fujiwara
Jun 25, 2002·European Journal of Pharmacology·Motoko HondaHideki Ono
Oct 19, 1999·Brain Research. Brain Research Reviews·R J Schuerger, C D Balaban
Apr 4, 2003·Behavioural Brain Research·Miguel Carro-Juáreza, Gabriela Rodríguez-Manzo
May 30, 2002·Progress in Neurobiology·Mark J Millan
Oct 3, 2008·Journal of Neurophysiology·Jacob G McPhersonJulius P A Dewald
Feb 7, 2002·Japanese Journal of Pharmacology·M Tanabe, T Kaneko
Nov 26, 2013·Archives of Physical Medicine and Rehabilitation·Virginia Way Tong ChuBrian David Schmit
May 24, 2011·Human Movement Science·Lynn M RogersDavid A Brown
Nov 2, 2005·The Journal of Pharmacy and Pharmacology·Jorge A Calasans-MaiaRoberto T Sudo
Jun 14, 2014·Frontiers in Neural Circuits·Eva Meier Carlsen, Jean-François Perrier
Oct 22, 2004·European Journal of Pharmacology·Motoko HondaHideki Ono
Sep 29, 2004·Synapse·Eric A StoneDavid Quartermain
Mar 4, 2003·Journal of Neurophysiology·Ian D HentallBrian R Noga
Mar 28, 2008·The Journal of Pharmacology and Experimental Therapeutics·Nicolas P LapointePierre A Guertin
Dec 16, 2011·Physiology·Gareth B Miles, Keith T Sillar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.